Case Report
Volume 4 Issue 9 - 2021
Mucinous Adenocarcinoma of Gall Bladder with Metastasis to Lymph Nodes and Liver: A Rare Case Report
Mansi Faujdar, Shubha Gupta, Ruchi Kumawat, Rohit Jain* and GN Gupta
Department of Pathology and Transfusion Medicine, Santokba Durlabhji Memorial Hospital and Medical Research Institute, Jaipur, India
*Corresponding Author: Rohit Jain, Department of Pathology and Transfusion Medicine, Santokba Durlabhji Memorial Hospital and Medical Research Institute, Jaipur, India.
Received: July 05, 2021; Published: August 30, 2021




Abstract

Gall bladder Cancer is the most malignant tumor of the bile duct worldwide. Mucinous adenocarcinoma of gall bladder is a very rare variant of gall bladder carcinoma. We report a case of 38 year old male who presented with complaints of pain in right hypochondrium, nausea and vomiting since 20 days. USG and CT scan revealed a mass in neck of gall bladder which on histopathological examination, showed Mucinous Adenocarcinoma metastasizing to liver and lymph nodes. To the best of our knowledge, this is the 26th case reported case of Mucinous carcinoma of gall bladder in the medical literature in the world.

Keywords: Mucinous Adenocarcinoma; Gall Bladder; Lymph Nodes; Liver

References

  1. CHE Lai and WY Lau. “Gallbladder cancer—a comprehensive review”. Surgeon2 (2008): 101-110.
  2. AX Zhu., et al. “Current management of gallbladder carcinoma”. The Oncologist 2 (2010): 168-181.
  3. TANGDE Ashwini Radhakishan., et al. “Current Mucinous adenocarcinoma of gall bladder: a case report”. International Journal of Research in Medical Sciences 11 (2017): 5082-5084.
  4. Rani Kanthan., et al. “Current Gallbladder Cancer in the 21st Century” (2015): 26.
  5. Gallbladder Cancer, American Cancer Society (2015).
  6. Guptae AP., et al. “Current Pure mucinous (colloid) adenocarcinoma of the gall bladder- a rare phenotype”. Oncology, Gastroenterology and Hepatology Reports 2 (2013): 27.
  7. Dursun N., et al. “Current Mucinous carcinomas of the Gallbladder: clinicopathologic analysis of 15 cases identified in 606 carcinomas”. Archives of Pathology and Laboratory Medicine 136 (2012): 1347-1358.
  8. Brunicardi FC and Anderson DK. “Schwartz’s Principles of Surgery”. (8th edition) McGraw-Hill’s, California USA ().
  9. AX Zhu., et al. “Current management of gallbladder carcinoma”. The Oncologist 2 (2010): 168-181.
  10. U Dutta. “Gallbladder cancer: can newer insights improve the outcome?” Journal of Gastroenterology and Hepatology 4 (2012): 642-653.
  11. SP Kaushik. “Current perspectives in gallbladder carcinoma”. Journal of Gastroenterology and Hepatology 8 (2001): 848-854.
  12. T Rustagi and CA Dasanu. “Risk factors for gallbladder cancer and cholangiocarcinoma: similarities, differences and updates”. Journal of Gastrointestinal Cancer2 (2012): 137-147.
  13. R Hundal and EA Shaffer. “Gallbladder cancer: epidemiology and outcome”. Clinical Epidemiology1 (2014): 99-109.
  14. MJ Kim., et al. “Current Unusual malignant tumors of the gallbladder”. American Journal of Roentgenology2 (2006): 473-480.
  15. Albores-Saavedra J., et al. “Current Carcinoma of the gallbladder and extrahepatic bile ducts”. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (editions.). World Health Organization Classification of Tumours of the Digestive System. (4th edition) WHO Press, Geneva (2010): 263-278.
  16. Adsay VN and Klimstra DS. “Benign and Malignant Tumors of the Gallbladder and Extrahepatic Biliary Tract”. In: Odze RD, Goldblum JR (editions.). Surgical pathology of the GI tract, liver, biliary tract, and pancreas. (2nd edition) Saunders Elsevier, Philadelphia (2009): 857-870.
  17. Adsay VN. “Gallbladder, Extrahepatic Biliary Tree, and Ampulla”. In: Mills SE, editor. Sternberg’s Diagnostic Surgical Pathology. (5th edition) Lippincott Williams and Wilkins. Philadelphia (2010): 1620-1624.
  18. Anand A and Agarwal K. “Mucinous Adenocarcinoma of Gall Bladder: A Rare Case Report”. Diagnostic Pathology is an Open 3 (2018): 148.
  19. Jagtap S A., et al. “Current Mucinous Adenocarcinoma of Gall Bladder – A rare Histopathological variant presented as perforation”. Journal of Clinical and Diagnostic Research 5 (2019): 07-09.
  20. Gupta R., et al. “Current Mucinous Adenocarcinoma of Gallbladder Presenting As Acute Calculous Cholecystitis”. Cureus4 (2021): e14548.
  21. Sharma M., et al. “Current Mucinous carcinoma of the gall Bladder – two rare case reports”. Journal of Cancer Research and Therapeutics.
  22. Albores-Saavedra J., et al. “Current Carcinoma of the gallbladder and extrahepatic bile ducts”. In: Hamilton SR, Aaltonen LA, editors. WHO Classification of Tumors. Pathology and Genetics of Tumors of the Digestive system. Lyon: IARC Press (2000): 206-212.
  23. Blechacz B and Gores GJ. “Tumors of the bile ducts, gallbladder, and ampulla”. Gastrointestinal and Liver Disease 8 (2010): 1171-1183.
  24. Barcia JJ., et al. “Current Gallbladder carcinoma in the “hospital de clinicas” of Uruguay: 1998–2002. A clinicopathologic study of five cases in 802 cholecystectomies”. Annals of Diagnostic Pathology1 (2004): 1-5.
  25. Joo YE., et al. “Current Case of mucinous adenocarcinoma with porcelain gallbladder”. Journal of Gastroenterology and Hepatology8 (2003): 995-998.
  26. Yamamoto A., et al. “Current A case of well differentiated mucinous carcinoma of the gallbladder. Nihon Shokakibyo Gakkai zasshi”. Japanese Journal of Gastroenterology and Hepatology11 (2010): 1821-1827.
  27. Nevra Dursun., et al. “Current Mucinous Carcinomas of the Gallbladder: Clinicopathologic Analysis of 15 Cases Identified in 606 Carcinomas”. Archives of Pathology and Laboratory Medicine11 (2012): 1347-1358.
Citation: Rohit Jain., et al. “Mucinous Adenocarcinoma of Gall Bladder with Metastasis to Lymph Nodes and Liver: A Rare Case Report”. EC Clinical and Medical Case Reports 4.9 (2021): 01-07.

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