Case Report
Volume 3 Issue 11 - 2020
Pulmonary Hyalinizing Granulomas (PHG): A Case Report and Review of the Literature
Ahmed Abduljabbar1, Mohammed Wazzan1, Khaled Mohammed Bahubaishi2, Mohammed Jamil Addas3*, Ibrahim Alghamdi2 and Malik Jamil Addas4
1Associate Professor and Consultant Radiology, King Abdulaziz University Hospital, KSA, Jeddah, Saudi Arabia
2Radiology Resident, King Abdulaziz University Hospital, KSA, Jeddah, Saudi Arabia
3Radiology Trainee (Attachment), King Abdulaziz University Hospital, KSA, Jeddah, Saudi Arabia
4Medical Student, King Abdulaziz University Hospital, KSA, Jeddah, Saudi Arabia
*Corresponding Author: Mohammed Jamil Addas, Radiology Trainee (Attachment), King Abdulaziz University Hospital, KSA, Jeddah, Saudi Arabia.
Received: September 23, 2020; Published: October 31, 2020


Background: Pulmonary hyalinizing granuloma (PHG) is a benign and rare disease that has an unknown cause. It presents as distinct nodules rounded in shape within the parenchyma of the lung [1]. It sometimes presets as single and sometimes numerous pulmonary nodules [6]. It is seen in patients of middle age and is usually symptomatic. Radiologically, it appears as numerous, bilateral nodules that might look like lung neoplasms [2].

Case Description: PHG is a non-infectious, non-common, fibrosing lung lesion. It might look like malignancy on imaging studies.

Conclusion: PHG is a rare non-infectious benign fibrosing lesion of the lung. It can sometimes mimic lung malignancy.

Keywords: Pulmonary Hyalinizing Granuloma (PHG); Parenchyma of the Lung


  1. Christopher Coleman., et al. “Pulmonary Hyalinizing Granuloma Associated with Idiopathic Thrombocytopenic Purpura”. Journal of Clinical Imaging Science4 (2014): 8.
  2. Uzer F., et al. “Pulmonary Hyalinizing Granuloma in the Differential Diagnosis of Pulmonary Carcinoma”. Clinical Medical Reviews and Case Reports 5 (2018): 209.
  3. D Agrawal., et al. “Pulmonary hyalinizing granuloma with ureteric fibrosis: a case report and review of relevant literature”. The Indian Journal of Chest Diseases and Allied Sciences4 (2006): 283-285.
  4. Ahn June Hong MD., et al. “A first case report of pulmonary hyalinizing granuloma associated with immunoglobulin A nephropathy”. Medicine49 (2017): e9088.
  5. Samuel A Yousem and Liselotte Hochholzer. “Pulmonary Hyalinizing Granuloma”. American Journal of Clinical Pathology1 (1987): 1-6.
  6. Düzgün Nuri., et al. “Pulmonary Hyalinizing Granuloma Mimicking Metastatic Lung Cancer”. Case Reports in Pulmonology (2015): 610417.
  7. Engleman P., et al. “Pulmonary hyalinizing granuloma”. The American Review of Respiratory Disease6 (1977): 997-1008.
  8. Lhote Raphael., et al. “Pulmonary hyalinizing granuloma: a multicenter study of 5 new cases and review of the 135 cases of the literature”. Immunologic Research1 (2017): 375-385.
  9. Brandão Viviane., et al. “Hyalinizing granuloma: an unusual case of a pulmonary mass”. Case Reports in Medicine (2010): 984765.
  10. Na Kook Joo., et al. “Subpleural pulmonary hyalinizing granuloma presenting as a solitary pulmonary nodule”. Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer 8 (2007): 777-779.
  11. Ren Y., et al. “Pulmonary small lymphocytic lymphoma (mucosa-associated lymphoid tissue type) associated with pulmonary hyalinizing granuloma”. Chest 3 (2001): 1027-1030.
  12. Drasin H., et al. “Pulmonary hyalinizing granulomas in a patient with malignant lymphoma, with development nine years later of multiple myeloma and systemic amyloidosis”. Cancer 1 (1979): 215-220.
  13. Kaneta Toshikado., et al. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 10 (2009): 953-959.
  14. Shinohara Takeshi., et al. “Pulmonary hyalinizing granuloma with laryngeal and subcutaneous involvement: report of a case successfully treated with glucocorticoids”. Internal Medicine1 (2004): 69-73.
  15. Esme Hidir., et al. “A case of pulmonary hyalinizing granuloma associated with posterior uveitis”. The Tohoku Journal of Experimental Medicine 1 (2004): 93-97.
Citation: Mohammed Jamil Addas., et al. “Pulmonary Hyalinizing Granulomas (PHG): A Case Report and Review of the Literature”. EC Clinical and Medical Case Reports 3.11 (2020): 69-75.

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