Research Article
Volume 3 Issue 9 - 2020
Protective Effect of Shenqi Fuzheng Injection on Myocardial Depression with Septic Shock
Jiang Li1,2*, Kang Zhiqin1 and Wang Jiani1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China
2Chongqing Medical University, Chongqing, China
*Corresponding Author: Jiang Li, The First Affiliated Hospital of Dalian Medical University, Chongqing, China.
Received: July 25, 2020; Published: August 27, 2020


Objective: This study aimed to evaluate whether Shenqi Fuzheng injection (SFI) could improve sepsis-induced myocardial depression (SIMD) in patients with septic shock.

Methods: A total of 361 patients who were admitted into the intensive care unit at the First Affiliated Hospital of Dalian Medical University between January 2012 and December 2017 were included in the study. All patients met the Sepsis 3.0 diagnostic criteria and were classified into an SFI group and a non-SFI group. The hemodynamic parameters, cardiac biochemical markers, echocardiography, Acute physiology and chronic health evaluation II (APCHE II) scores, sequential organ function assessment (SOFA) and prognosis were compared between the groups 12, and 24 and 72 hours after receiving treatment.

Results: SOFA and cardiac related markers, including brain natriuretic peptide (BNP), creatine kinase (CK) and CK-muscle/brain (MB) were significantly lower in the SFI group than in the non-SFI group (P < 0.05). Left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV) and lactate were significantly decreased in patients treated with SFI compared to those with non-SFI. SFI shortened the duration of ICU stay and improved 28-day survival (P < 0.05).

Conclusion: SFI improves the survival of patients with septic shock by improving SIMD and microcirculation.


Keywords: Septic Shock; Sepsis-Induced Myocardial Depression; Shenqi Fuzheng Injection (SFI); Fluid Resuscitation


  1. Rhodes A., et al. “Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016”. Intensive Care Medicine 43 (2017): 304-377.
  2. Wang Z., et al. “[Impacts of sepsis-induced myocardial dysfunction on hemodynamics, organ function and prognosis in patients with septic shock]”. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 27 (2015): 180-184.
  3. Vieillard-Baron A., et al. “Actual incidence of global left ventricular hypokinesia in adult septic shock”. Critical Care Medicine 36 (2008): 1701-1706.
  4. Li L., et al. “Role of mitochondrial damage during cardiac apoptosis in septic rats”. Chinese Medical Journal 126 (2013): 1860-1866.
  5. Liao J., et al. “Network pharmacology study reveals energy metabolism and apoptosis pathways-mediated cardioprotective effects of Shenqi Fuzheng”. Journal of Ethnopharmacology 227 (2018): 155-165.
  6. Yang Y., et al. “Immunoregulation of Shenqi Fuzheng Injection Combined with Chemotherapy in Cancer Patients: A Systematic Review and Meta-Analysis”. Evidence-Based Complementary and Alternative Medicine (2017): 5121538.
  7. Zhang J., et al. “Shenqi fuzheng injection attenuates irradiation-induced brain injury in mice via inhibition of the NF-kappaB signaling pathway and microglial activation”. Acta Pharmaceutica Sinica B 36 (2015): 1288-1299.
  8. Deutschman CS and Tracey KJ. “Sepsis: current dogma and new perspectives”. Immunity 40 (2014): 463-475.
  9. Wang S and Li G. “[Clinical research progress of septic cardiomyopathy]”. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 27 (2015): 1019-1021.
  10. Lu ZQ., et al. “Glucocorticoids offer protection against myocardial injury in a murine model of sepsis”. International Journal of Clinical and Experimental Medicine 8 (2015): 12211-12218.
  11. Hobai IA., et al. “Lipopolysaccharide and cytokines inhibit rat cardiomyocyte contractility In vitro”. The Journal of Surgical Research 193 (2015): 888-901.
  12. Ng SC., et al. “Review article: the role of non-biological drugs in refractory inflammatory bowel disease”. Alimentary Pharmacology and Therapeutics 33 (2011): 417-427.
  13. Rutgeerts P., et al. “Infliximab for induction and maintenance therapy for ulcerative colitis”. The New England Journal of Medicine 353 (2005): 2462-2476.
  14. Charpentier J., et al. “Brain natriuretic peptide: A marker of myocardial dysfunction and prognosis during severe sepsis”. Critical Care Medicine 32 (2004): 660-665.
  15. Ait-Oufella H., et al. “The endothelium: physiological functions and role in microcirculatory failure during severe sepsis”. Intensive Care Medicine 36 (2010): 1286-1298.
  16. Johannes T., et al. “Nonresuscitated endotoxemia induces microcirculatory hypoxic areas in the renal cortex in the rat”. Shock 31 (2009): 97-103.
  17. Dahl KN., et al. “Mechanobiology and the microcirculation: cellular, nuclear and fluid mechanics”. Microcirculation 17 (2010): 179-191.
  18. Soga T., et al. “The relationship between hyperlactatemia and microcirculation in the thenar eminence as measured using near-infrared spectroscopy in patients with sepsis”. Emergency Medicine Journal 31 (2014): 654-658.
Citation: Jiang Li., et al. “Protective Effect of Shenqi Fuzheng Injection on Myocardial Depression with Septic Shock”. EC Clinical and Medical Case Reports 3.9 (2020): 64-73.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

April Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the April issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before April 22, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to