Research Article
Volume 3 Issue 9 - 2020
Protective Effect of Shenqi Fuzheng Injection on Myocardial Depression with Septic Shock
Jiang Li1,2*, Kang Zhiqin1 and Wang Jiani1
1The First Affiliated Hospital of Dalian Medical University, Dalian, China
2Chongqing Medical University, Chongqing, China
*Corresponding Author: Jiang Li, The First Affiliated Hospital of Dalian Medical University, Chongqing, China.
Received: July 25, 2020; Published: August 27, 2020




Abstract

Objective: This study aimed to evaluate whether Shenqi Fuzheng injection (SFI) could improve sepsis-induced myocardial depression (SIMD) in patients with septic shock.

Methods: A total of 361 patients who were admitted into the intensive care unit at the First Affiliated Hospital of Dalian Medical University between January 2012 and December 2017 were included in the study. All patients met the Sepsis 3.0 diagnostic criteria and were classified into an SFI group and a non-SFI group. The hemodynamic parameters, cardiac biochemical markers, echocardiography, Acute physiology and chronic health evaluation II (APCHE II) scores, sequential organ function assessment (SOFA) and prognosis were compared between the groups 12, and 24 and 72 hours after receiving treatment.

Results: SOFA and cardiac related markers, including brain natriuretic peptide (BNP), creatine kinase (CK) and CK-muscle/brain (MB) were significantly lower in the SFI group than in the non-SFI group (P < 0.05). Left ventricular ejection fraction (LVEF), left ventricular end diastolic volume (LVEDV) and lactate were significantly decreased in patients treated with SFI compared to those with non-SFI. SFI shortened the duration of ICU stay and improved 28-day survival (P < 0.05).

Conclusion: SFI improves the survival of patients with septic shock by improving SIMD and microcirculation.

 

Keywords: Septic Shock; Sepsis-Induced Myocardial Depression; Shenqi Fuzheng Injection (SFI); Fluid Resuscitation

References

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Citation: Jiang Li., et al. “Protective Effect of Shenqi Fuzheng Injection on Myocardial Depression with Septic Shock”. EC Clinical and Medical Case Reports 3.9 (2020): 64-73.

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