Case Report
Volume 3 Issue 9 - 2020
Osteosarcoma of Left Metatarsal Bone. A Case Report
Chhaya Rani Shevra1*, Akansha Srivastav2 and Mayank Singh3
1Assistant Professor, Department of Pathology, MLB Medical College, Jhansi, India
2Junior Resident, Department of Pathology, MLB Medical College, Jhansi, India
3Professor and Head, Department of Pathology, MLB Medical College, Jhansi, India
*Corresponding Author: Chhaya Rani Shevra, Assistant Professor, Department of Pathology, MLB Medical College, Jhansi, India.
Received: June 20, 2020; Published: August 28, 2020


Osteosarcoma is the most common primary malignant bone tumor characterized by the formation of osteoid. The tumor affects mainly adolescents and young patients it occurs mainly in long bones and involvement of metatarsal bones is rare. Amongst the metatarsal bone the calcaneus is the most common bone involved. Males are more affected by osteosarcoma than females. We report a rare case of a 55 year-old male with chief complain of on and off pain and swelling of the left foot. After surgical excision, histopathological evaluation of the lesion revealed the lesion as malignant bone tumor osteosarcoma. We herein describe the unusual presentation of the osteosarcoma of left foot in a 55 year old male which was diagnosed by histopathological findings along with the radiological findings.

Keywords: Osteosarcoma; Metatarsal; Bone Tumor; Osteoid; Sarcoma


  1. Kumar V. “Pathologic Basis of Disease”. Saunders (2013): 776-777.
  2. Rosai J. “Rosai and Ackerman's Surgical Pathology”. 10th edition; Elsevier, Inc (2013): 2024-2032.
  3. Klein MJ and Siegal GP. “Osteosarcoma: anatomic and histologic variants”. American Journal of Clinical Pathology 125 (2006): 555-581.
  4. Picci P. “Osteosarcoma (Osteogenic Sarcoma)”. Orphanet Journal of Rare Diseases (2007): 2-6. 
  5. Sugano I., et al. “Phalangeal intraosseous well-differentiated osteosarcoma of the hand”. Virchows Arch 430 (1997): 185-189. 
  6. K Anninga., et al. “Osteosarcoma of the hands and feet: a distinct clinico-pathological subgroup”. Virchows Archiv (2013): 109-120.
  7. Brotzmann., et al. “Do malignant bone tumors of the foot have a different biological behavior than sarcomas at other skeletal sites?”. Sarcoma (2013): 767960.
  8. LB Chou., et al. “Tumors of the foot and ankle: experience with 153 cases”. Foot and Ankle International (2009): 836-841.
  9. R Eyre., et al. “Epidemiology of bone cancer in 0-39 year olds in northern England,1981–2002”. BMC Cancer (2017): 357.
  10. Abe K., et al. “High-grade surface osteosarcoma of hand”. Skeletal Radiology 36 (2000): 869-873.
  11. Nakjima H., et al. “Small cell osteosarcoma of bone. Review of 72 cases”. Cancer 79 (1997): 2095-2106. 
  12. Biscaglia R., et al. “Osteosarcoma of the bones of the foot-an easily misdiagnosed malignant tumor”. Mayo Clinic Proceedings 73 (1998): 842-847.
  13. Ruggieri P., et al. “Review of foot tumors seen in a university tumor institute”. The Journal of Foot and Ankle Surgery 53 (2014): 282-285. 
  14. Azevedo CP., et al. “Tumors of the foot and ankle: a single-institution experience”. The Journal of Foot and Ankle Surgery 52 (2013): 147-152.
  15. L Kager., et al. “Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols”. Journal of Clinical Oncology (2003): 2011-2018.
Citation: Chhaya Rani Shevra., et al. “Osteosarcoma of Left Metatarsal Bone. A Case Report”. EC Clinical and Medical Case Reports 3.9 (2020): 09-13.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

April Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the April issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before April 22, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to