Research Article
Volume 3 Issue 9 - 2020
Antimicrobial Effect of Ear Wax (Cerumen auris) on Some Animal Pathogens
Rehab Mohamed Atta El-Desoukey1*, Afnan F Alqhtani2, Alanoud M Alqhtani2, Bayan B Algabiri2, Rola S Alqhtani2, Sadeem S Alsuhaimi2, Shahad A Alrabia2, Ozof A Alghtani2, Faiza KU Hamid2, Latifah A Alhuomaid2, Hala A Alsahli2 and Wafa F Alqhtani2
1Microbiology and Immunology Department, National Research Center, Giza, Egypt
2Biology Department, Faculty of Science and Humanities in Al Quwai’iyah, Shaqraa University, KSA
*Corresponding Author: Rehab Mohamed Atta El-Desoukey, Microbiology and Immunology Department, National Research Center, Giza, Egypt.
Received: June 20, 2020; Published: August 20, 2020


One of the basic issues in the clinical world including veterinary medicine is spreading of bacterial resistance against antibiotics, so one of the most significant strides in microbiological is to locate another antimicrobial agent with minimal side effects. Earwax, alluded to as Cerumen auris, is a defensive typical emission from the outside sound-related waterway external third cartilaginous skin organ. It is a blend of primarily 60% desquamated, 12 - 20% soaked and unsaturated long-chain unsaturated fat and 6 - 9% cholesterol. It greases up the outer sound-related channel. It additionally traps dust with other little particles and creepy crawlies, subsequently keeping them from coming to and harming the eardrum. It likewise protects from tainting specialists, for example, bacteria and fungi. So, the aim of this study is to explore the antimicrobial effect of Earwax (Cerumen auris) on some clinically significant animal pathogen. Ear wax suspension was assessed for their antimicrobial action against Staphylococcus aureus, Bacillus, Salmonella, Klebsiella and Pseudomonas isolated from animals by agar well diffusion method. The results have demonstrated that the antimicrobial impact of ear wax suspension revealed exceptionally huge against Bacillus followed by Salmonella and Klebsiella with similarly impact while there is no antimicrobial effect of the suspension on both Staph and Pseudomonas. So, it very well may be presumed that other than being a physical obstruction, cerumen works like defensive covering over the outside sound-related trench because of its antibacterial properties.

Keywords: Earwax; Cerumen auris; Staphylococcus aureus; Bacillus; Salmonella; Klebsiella; Antimicrobial and Pseudomonas


  1. Parastoo Karimi Alavijeh., et al. “A study of antimicrobial activity of few medicinal herbs”. Asian Journal of Plant Science and Research 2 (2012): 496-502.
  2. Singh M., et al. “The spectrum of antibiotic resistance in human and veterinary isolates of coli collected from 1984-1986 in northern India”. Journal of Antimicrobial Chemotherapy 29 (1992): 159-168.
  3. Mulligen ME., et al. “Methecillin resistant Staphylococcus aureus”. American Journal of Medicine 94 (1993): 313-328.
  4. Alvord LS and Farmer BL. “Anatomy and orientation of the human external ear”. The Journal of the American Academy of Audiology 8 (1997): 383-390.
  5. Burkhart CN., et al. “Cerumen composition by flash pyrolysis-gas chromatography/mass spectrometry”. Otology and Neurotology 22 (2001): 715-722.
  6. Sirigu P., et al. “Local immune response in the skin of the external auditory meatus: An immunohistochemical study”. Microscopy Research and Technique 38 (1997): 329-334.
  7. Tomita H., et al. “Mapping of the wet/dry earwax locus to the pericentromeric region of chromosome 16”. Lancet 359 (2002): 2000-2002.
  8. Petrakis NL., et al. “Evidence for a genetic cline in earwax types in the Middle East and Southeast Asia”. American Journal of Physical Anthropology 35 (1971): 141-144.
  9. Cipriani C., et al. “Production rate and composition of cerumen: Influence of sex and season”. Laryngoscope 100 (1990): 275-276.
  10. Lum CL., et al. “Antibacterial and antifungal properties of human cerumen”. The Journal of Laryngology and Otology 123 (2009): 375-378.
  11. Gupta S., et al. “A study of antibacterial and antifungal properties of human cerumen”. Indian Journal of Otology 18 (2012): 189-192.
  12. Zaika L. “Spices and herbs: their antimicrobial activity and its determination”. The Journal of Food Safety 9 (1988): 97-118.
  13. Campos A., et al. “Study of common aerobic flora of human cerumen”. The Journal of Laryngology and Otology 112 (1998): 613-616.
  14. Bojrab DI., et al. “Otitis externa”. Otolaryngologic Clinics of North America 29 (1996): 761-782.
  15. Lindsey D. “It's time to stop washing out ears!” American Journal of Emergency Medicine 9 (1991): 297.
  16. Osborne JE and Baty JD. “Do patients with otitis externa produce biochemically different cerumen?” Clinical Otolaryngology and Allied Sciences 15 (1990): 59-61.
  17. Sokolov VE., et al. “The anti-infective properties of mammalian earwax”. Izvestiia Akademii Nauk Seriia Biologicheskaia 5 (1995): 579-585.
  18. Stone M and Fulghum RS. “Bactericidal activity of wet cerumen”. Annals of Otology, Rhinology, and Laryngology 93 (1984): 183-186.
  19. Chai TJ and Chai TC. “Bactericidal activity of cerumen”. Antimicrobial Agents and Chemotherapy 18 (1980): 638-641.
  20. Baumann ES., et al. “Studies of factors considered responsible for diseases of the external auditory canal. III. A comparison of lipids in normal and infection-susceptible ears”. Annals of Otology, Rhinology, and Laryngology 70 (1961): 1055-1061.
  21. Campos A., et al. “Influence of human wet cerumen on the growth of common and pathogenic bacteria of the ear”. The Journal of Laryngology and Otology 114 (2000): 925-999.
  22. Burtenshaw JM. “The mechanism of self-disinfection of the human skin and its appendages”. The Journal of Hygiene 42 (1942): 184-210.
  23. Megarry S., et al. “The activity against yeasts of human cerumen”. The Journal of Laryngology and Otology 102 (1988): 671-672.
  24. Nichols AC and Perry ET. “Studies on the growth of bacteria in the human ear canal”. Journal of Investigative Dermatology 27 (1956): 165-170.
Citation: Rehab Mohamed Atta El-Desoukey., et al. “Antimicrobial Effect of Ear Wax (Cerumen auris) on Some Animal Pathogens”. EC Clinical and Medical Case Reports 3.9 (2020): 01-06.

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