Review Article
Volume 3 Issue 8 - 2020
Comparative Study of Valacyclovir and Acyclovir for the Improves Therapy of Herpes Zoster in an Immunocompetent Adult
Umama Yezdani1*, Karthikeyan Lakshmanan2, Hari Baskar3, Gulafsha Fatima1, Shareefa Habeeba1, Mukilan D4, Nazima Fatima1, Noor Us Sabah1 and Mohammad Gayoor Khan5
1Department of Pharmacy Practice, MRM College of Pharmacy, Hyderabad, Telangana, India
2Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
3Department of Pharmacy, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India
4Department of Pharmacy Practice, Vels Institute of Science Technology and Advanced Studies, Chennai, Tamil Nadu, India
5Department of Pharmacy, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, India
*Corresponding Author: Umama Yezdani, Department of Pharmacy Practice, MRM College of Pharmacy, Hyderabad, Telangana, India.
Received: July 07, 2020; Published: July 31, 2020


Herpes zoster is a kind of viral infection which is known to occur due to the reactivation of virus named varicella zoster virus. This is normally very painful self-limited dermatomal rash. Usually the rashes occur on the body and face, they appear to be in the form of single, wide stripe. Patients who have some other underlying conditions which decrease the cell mediated immunity have 20 to 100 times more chances of getting herpes zoster. Herpes zoster can be treated by acyclovir and its speed of recovery increases when it is taken in early stages of infection and speeds up healing up of rash and decreases pain. As acyclovir has reduced oral bioavailability because of this it requires frequent dosing. Valaciclovir is the form which has more bioavailability almost three to five folds. Valaciclovir is a modified product of acyclovir and after oral administration is rapidly converted to acyclovir in the gastrointestinal tract. Thus, the bioavailability of acyclovir is three to five times greater after the oral intake of valaciclovir compared to taking acyclovir alone. Acyclovir (standard dose for herpes zoster ophthalmicus: 800 mg five times daily for seven to 10 days) and valaciclovir (standard dose for herpes zoster ophthalmicus: 1000 mg three times daily for seven days) have been approved for the treatment of herpes zoster and are widely used. Valacyclovir exhibits the same favorable toxicity profile as acyclovir.

Following absorption, valaciclovir is completely converted to acyclovir and the essential amino acid, L-valine. Other than acyclovir there are other drugs like valacyclovir treats within 72 hours of the development of rash. Thus, in the management of immunocompetent patients > or = 50 years of age with localized herpes zoster, while valaciclovir given in 1,000 mg thrice a day for 7 days increases the reduction of pain and also has simple dosing and also provide favorable safety conditions.

Keywords: Herpes Zoster; Dermatomal Rash; Bioavailability; Acyclovir; Valacyclovir; Immunocompetent; L Valine


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Citation: Umama Yezdani., et al. “Comparative Study of Valacyclovir and Acyclovir for the Improves Therapy of Herpes Zoster in an Immunocompetent Adult”. EC Clinical and Medical Case Reports 3.8 (2020): 131-138.

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