Research Article
Volume 3 Issue 6 - 2020
Dermatomyositis Complicated by Calcinosis: Keys to the Therapeutic Challenge
Aamir Jalal Al Mosawi1,2*
1Advisor in Pediatrics and Pediatric Psychiatry, Children Teaching Hospital of Baghdad Medical City, Baghdad, Iraq
2Head, Iraq Headquarter of Copernicus Scientists International Panel, Baghdad, Iraq
*Corresponding Author: Aamir Jalal Al Mosawi, Advisor in Pediatrics and Pediatric Psychiatry, Children Teaching Hospital of Baghdad Medical City and Head, Iraq Headquarter of Copernicus Scientists International Panel, Baghdad, Iraq.
Received: May 05, 2020; Published: May 22, 2020




Abstract

Background: There is no curative therapy for dermatomyositis complicated by calcinosis. Many patients with such disorders will continue to have some symptoms. In Iraq many specialist physicians may have limited experience with treatment of such disorders and treatment side effects of log term treatment can be sometimes encountered. It is hoped that advances associated with the accumulating research evidence can help in improving treatment of such conditions.

Materials and Methods: A unique case of pediatric dermatomyositis associated with calcinosis that was referred because treatment was unsatisfactory and was associated with serious side effects was studied. The medical literatures were reviewed for the research evidence suggesting possible therapeutic interventions than improve this condition.

Results: The occurrence of pediatric dermatomyositis associated with calcinosis has not been well documented in Iraq. RH is an eight-year old who had dermatomyositis associated with calcinosis and complicated by bilateral osteonecrosis of the hip joints, pericardial effusion, and chronic hematoma at the right ankle. The girl was treated before referral by some of the traditional therapies that improved her symptoms early in the course of illness, but treatment was associated remissions and relapses and she experienced serious side effects of long-term treatment.

Conclusion: Research evidence suggests several possible therapies for the treatment of dermatomyositis complicated calcinosis despite long-term prednisolone and methotrexate. The choice of the option may have to be individualized as it may depend on the experience of the treating physician, the availability of the medications. As a first line we suggest the use of Adrenocorticotropic hormone (ACTH) combined with probenecid and aluminium hydroxide as a first line.

Keywords: Dermatomyositis; Calcinosis; Osteonecrosis of Hips; Pericardial Effusion

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Citation: Aamir Jalal Al Mosawi. “Dermatomyositis Complicated by Calcinosis: Keys to the Therapeutic Challenge”. EC Clinical and Medical Case Reports 3.6 (2020): 97-102.

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