Research Article
Volume 3 Issue 6 - 2020
Comparative Effectiveness of Methotrexate Hydroxychloroquine Leflunomide Combined Treatment for the Arthritis with Small Dose of Corticosteroid
Noor US Sabah1*, Karthikeyan Lakshmanan2, Hari Baskar3, Shareefa Habeeba1, Gulafsha Fatima1, Mohammad Gayoor Khan4, Umama Yezdani1, Mukilan D5 and Nazima Fatima1
1Department of Pharmacy Practice, MRM College of Pharmacy, Hyderabad, Telangana, India
2Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
3Department of Pharmacy, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India
4Department of Pharmacy, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, India
5Department of Pharmacy Practice, Vels Institute of Science Technology and Advanced Studies, Chennai, Tamil Nadu, India
*Corresponding Author: Noor US Sabah, Department of Pharmacy Practice, MRM College of Pharmacy, Hyderabad, Telangana, India.
Received: April 29, 2020; Published: May 09, 2020


Rheumatoid Arthritis (RA) is a chronic disabling inflammatory arthritis, which is associated with significant morbidity and increased mortality. Disease severity is based on the number of joints involved and the extent of pain associated with it and how it affects the daily life activities. The disease severity can be assessed using different calculators like DAS28, CDAI, SDAI, and RAPID 3. Different DMARD’S are used in the treatment of Rheumatoid Arthritis alone or in combination. Biologic DMARD’S are efficacious but are too costly and hence most often synthetic DMARD’S are used. The present study seeks to analyze the efficacy of different DMARD’S used alone or in combination, with simultaneous administration of low dose corticosteroid. The efficacy is assessed based on the ability of DMARD(S) to reduce the disease severity. The disease severity was assessed at baseline and at follow up after two months of initiation of therapy using RAPID 3 calculator.

Keywords: Rheumatoid Arthritis; Corticosteroid, Methotrexate (MTX); Leflunomide (LFM); Hydroxychloroquine (HCQ)


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Citation: Noor US Sabah., et al. “Comparative Effectiveness of Methotrexate Hydroxychloroquine Leflunomide Combined Treatment for the Arthritis with Small Dose of Corticosteroid”. EC Clinical and Medical Case Reports 3.6 (2020): 54-67.

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