Mini Review
Volume 3 Issue 6 - 2020
Effect of Metformin Treatment on the Serum Levels of Vitamin B12 and Folic Acid in Patients with Polycystic Ovary Syndrome
Hari Baskar1*, Shazia Inayath Khatoon2, Shareefa Habeeba2, Mukilan D3, Nazima Fatima2, Noor US Sabah2, Mohammad Gayoor Khan4, Umama Yezdani2 and Karthikeyan Lakshmanan5
1Department of Pharmacy, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India
2Department of Pharmacy Practice, MRM College of Pharmacy, Hyderabad, Telangana, India
3Department of Pharmacy Practice, Vels Institute of Science Technology and Advanced Studies, Chennai, Tamil Nadu, India
4Department of Pharmacy, Truba Institute of Pharmacy, Bhopal, Madhya Pradesh, India
5Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai, Tamil Nadu, India
*Corresponding Author: Hari Baskar, Department of Pharmacy, KMCH College of Pharmacy, Coimbatore, Tamil Nadu, India.
Received: April 29, 2020; Published: May 07, 2020


Polycystic ovary syndrome is a common endocrinological disorder of women characterised by menstrual abnormalities, hirsutism, anovulatory infertility with the presence of immature follicles in the enlarged ovaries. Metformin, a commonly used hypoglycemic agent, is employed in the treatment of PCOS since insulin resistance has been recognised as one of the contributing factors in the development of PCOS. Metformin also helps in maintaining proper ovulation by regulating the levels of LSH and FH. Use of Metformin in PCOS is associated with significant reduction in the serum levels of Vitamin B12 and Folic acid. Monitoring the levels of Serum Vitamin B12 and Folic acid in PCOS patients with metformin therapy and providing them with proper Vitamin B supplementation will prevent the occurrence of these conditions.

Keywords: Metformin; PCOS; Vitamin B12; Folic Acid


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Citation: Hari Baskar., et al. ““Effect of Metformin Treatment on the Serum Levels of Vitamin B12 and Folic Acid in Patients with Polycystic Ovary Syndrome”. EC Clinical and Medical Case Reports 3.6 (2020): 19-22.

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