Mini Review
Volume 3 Issue 6 - 2020
Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy in 2020
Sorin Cimpean1*, Kelly Ann Bobb2 and Guy-Bernard Cadiere1
1Saint Pierre University Hospital, Brussels, Belgium
2Eric Williams Medical Center Science Complex, Champ Fleurs, Trinidad and Tobago
*Corresponding Author: Sorin Cimpean, Digestive Surgery Department, Saint Pierre University Hospital, Brussels, Belgium.
Received: April 04, 2020; Published: May 04, 2020


Associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) is proposed as a surgical option for the patients with no other surgical option with failed portal vein embolization or extremely small future liver remnant. Since the first publication of the technique in 2012, this technique evolved nowadays to partial ALPPS and minimal-invasive ALPPS. Conventional two-stage hepatectomy remains a feasible option for older patients and those with a liver to body-weight-ratio of > 0,4.

Keywords: Associated Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS); Future Liver Remnant (FLR); Two- Stage Hepatectomy (TSH); Portal Vein Ligation (PVL)


  1. Baumgart J., et al. “Two-Stage Hepatectomy and ALPPS for Advanced Bilateral Liver Metastases: a Tailored Approach Balancing Risk and Outcome”. The Journal of Gastrointestinal Surgery 12 (2019): 2391‑400.
  2. Lopez-Lopez V., et al. “ALPPS for hepatocarcinoma under cirrhosis: a feasible alternative to portal vein embolization”. Annals of Translational Medicine 22 (2019): 691‑691.
  3. Lang H., et al. “Associated Liver Partition and Portal Vein Ligation for Staged Hepatectomy (ALPPS) Registry: What Have We Learned?” Gut and Liver (2020).
  4. Tomassini F., et al. “Hemodynamic changes in ALPPS influence liver regeneration and function: results from a prospective study”. HPB 5 (2019): 557‑565.
  5. Lang H., et al. “Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy in the Treatment of Colorectal Liver Metastases: Current Scenario”. Digestive Surgery 4 (2018): 294‑302.
  6. Hahn O., et al. “Speciális májműtét (Associating Liver Partition and Portal vein ligation for Staged hepatectomy, ALPPS)”. Orvosi Hetilap32 (2019): 1260‑1269.
  7. Huiskens J., et al. “Avoiding postoperative mortality after ALPPS-development of a tumor-specific risk score for colorectal liver metastases”. HPB7 (2019): 898‑905.
  8. Wu X., et al. “Partial ALPPS versus complete ALPPS for staged hepatectomy”. BMC Gastroenterology 1 (2019): 170.
  9. Peng C., et al. “The outcome of the HCC patients underwent ALPPS: Retrospective study”. Medicine 38 (2019): e17182.
  10. Nagino M. “Value of ALPPS in surgery for Klatskin tumours”. British Journal of Surgery 12 (2019): 1574‑1575.
  11. Lau WY. “Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and its further developments in the last decade”. HepatoBiliary Surgery and Nutrition 3 (2019): 258‑259.
  12. Chan ACY and Lo CM. “Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS)-pushing the envelope in modulation of future liver remnant before major hepatectomy”. HepatoBiliary Surgery and Nutrition 1 (2020): 80‑82.
  13. Baili E., et al. “Associating liver partition and portal vein ligation for staged hepatectomy in patients with primary liver malignancies: A systematic review of the literature”. Journal of the Balkan Union of Oncology 4 (2019): 1371-1381.
  14. Truant Stéphanie., et al. “Laparoscopic Partial ALPPS: Much Better Than ALPPS!”. Annals of Hepatology (2018).
  15. Bednarsch J., et al. “The role of ALPPS in intrahepatic cholangiocarcinoma”. Langenbeck's Archives of Surgery 7 (2019): 885‑894.
  16. Kumar N., et al. “Partial ALPPS with a longer wait between procedures is safe and yields adequate future liver remnant hypertrophy”. Annals of Hepato-Biliary-Pancreatic Surgery 1 (2019): 13.
  17. Giuliante F and Ardito F. “ALPPS Versus Conventional Two-stage Hepatectomy in Patients with Advanced Colorectal Liver Metastases”. Annals of Surgery1 (2019): 833-840.
  18. Huang H-C., et al. “Complete or partial split in associating liver partition and portal vein ligation for staged hepatectomy: A systematic review and meta-analysis”. World Journal of Gastroenterology 39 (2019): 6016‑6024.
  19. Xiang F and Hu Z-M. “Chance and challenge of associating liver partition and portal vein ligation for staged hepatectomy”. Hepatobiliary and Pancreatic Diseases International3 (2019): 214‑222.
  20. Borger P., et al. “Exploration of the Transcriptional Landscape of ALPPS Reveals the Pathways of Accelerated Liver Regeneration”. Frontiers in Oncology (2019): 1206.
  21. Lang H. “ALPPS - Beneficial or detrimental?” Surgical Oncology (2019): 30456-30466.
  22. Tomassini F., et al. “Hepatobiliary scintigraphy and kinetic growth rate predict liver failure after ALPPS: a multi-institutional study”. HPB (2020): 30029-30030.
Citation: Sorin Cimpean., et al. “Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy in 2020”. EC Clinical and Medical Case Reports 3.6 (2020): 01-04.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

April Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the April issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before April 26, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to