Case Series
Volume 3 Issue 6 - 2020
Necrotising Araneism of the Neck in Two Malagasy Children
Patrick Maholisoa Randrianandraina1*, Naharisoa Giannie Rasamimanana2, Hery Henintsoa Randrianirina3, Herisitraka Raotoson4, Tohaina Dolly Velonjara2 and Norotiana Rabesandratana5
1Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Mahajanga, Madagascar
2Department of Emergencies, University Hospital of Mahajanga, Madagascar
3Department of Anesthesia, University Hospital of Mahajanga, Madagascar
4Department of Maxillofacial Surgery, University Hospital of Mahajanga, Madagascar
5Department of Paediatrics, University of Mahajanga, Madagascar
*Corresponding Author: Patrick Maholisoa Randrianandraina, Department of Otorhinolaryngology Head and Neck Surgery, University Hospital of Mahajanga, Madagascar.
Received: March 18, 2020; Published: May 29, 2020


Objective: To report Clinical manifestation of necrotizing dermohypodermitis evoking a loxoscélisme and its management from two cases of araneism in children observed in Mahajanga hospital.

Observation: An 18-month-old child with no medical history was sawn for a necrotizing neck lesion. It was an ulcerated skin lesion of the neck which would have started with a lateral cervical inflammatory cup rapidly extensive for a week before this consultation. There was no biological trouble. Parents reported a spider bite before the lesion appeared. Local care with surgical excision of necrotic skin lesions allowed healing in 7 weeks.

One month later, a 24-month-old boy from the same region presented an inflammatory cervical skin lesion, necrotic in places, evolving for 5 days before this consultation. This child was tired and dehydrated but he was cognizant. He had no particular history. There was no infectious gateway. Brown spiders are present in their homes according to the parents. After resuscitation measures, local care and surgical excision of necrotic areas, a good scarring of the wound was observed.

Conclusion: The bite of spiders causes extensive skin necrosis under the effect of the venom injected into the skin. Extensive substance loss can result especially in children, whether or not associated with signs of systemic neurotoxicity. The management of araneism is multidisciplinary, but fumigation of homes could be a means of prevention.

Keywords: Envenomation; Spider Bite; Skin Necrosis


  1. Kaouadji K., et al. "Griffures et envenimations: conduite à tenir en urgence". Encyclopédie Médico Chirurgicale Médecine 4 (2004): 337‑351.
  2. De Haro L. "Aranéïsme en dermatologie: de nombreuses difficultés diagnostiques". Annales de Dermatologie et de Vénéréologie12 (2010): 765-767.
  3. Chippaux J-P. " Epidemiology of envenomations by terrestrial venomous animals in Brazil". Journal of Venomous Animals and Toxins Including Tropical Diseases13 (2015).
  4. Raveloson N., et al. "A propos de latrodectisme à Madagascar". Médecine d’Afrique Noire3 (2004): 164‑166.
  5. Nentwig W., et al. "Distribution and medical aspects of Loxosceles rufescens, one of the most invasive spiders of the world (Araneae: Sicariidae)". Toxicon 132 (2017): 19‑
  6. Leroy-Colavolpe V., et al. "Le loxoscelisme arrive dans le sud-ouest: à propos de cinq cas". Annales de Dermatologie et de Vénéréologie12 (2016): S344‑S3455.
  7. Belaid D., et al. "Loxoscélisme cutané: à propos de trois cas". Annales de Dermatologie et de Vénéréologie12 (2012): B237.
  8. Swanson D., et al. "Bites of Brown Recluse spiders and suspected necrotic arachnidism". New England Journal of Medicine7 (2005): 700‑707.
  9. Boissière F., et al. "Le loxoscelisme cutané, à propos d’une observation exceptionnelle de 9 cas consécutifs". Annales de Chirurgie Plastique et Esthétique6 (2016): 811‑819.
  10. Rahmani F., et al. "Poisonous Spiders: Bites, Symptoms, and Treatment; an Educational Review". Emergency 2 (2014): 54‑58.
  11. Pauli I., et al. "Analysis of therapeutic benefits of antivenin at different time intervals after experimental envenomation in rabbits by venom of he brown spider (Loxosceles inermedia)". Toxicon6 (2009): 660‑671.
Citation: Patrick Maholisoa Randrianandraina., et al. “Necrotising Araneism of the Neck in Two Malagasy Children”. EC Clinical and Medical Case Reports 3.6 (2020): 90-94.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

April Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the April issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before April 26, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to