Case Report
Volume 3 Issue 5 - 2020
Glioblastoma and Successful Cancer Immuno-Gene Therapy
Gabriela Quintero1,2, Andrea Guzman2, Annabelle Trojan2, Heliodor Kasprzak3 and Jerzy Trojan2,3*
1Faculty of Medicine, UNAB University, Floridablanca, Colombia
2ICGT Foundation Bogota/Paris and CEDEA SA Bogota, Colombia and France
3Faculty of Medicine, Department of Gene Therapy, UMK University, Bydgoszcz, Poland
*Corresponding Author: Jerzy Trojan, ICGT Foundation Bogota/Paris and CEDEA SA Bogota, Colombia and France.
Received: March 17, 2020; Published: April 15, 2020




Abstract

Targeting the Insulin-like Growth Factor1 (IGF-I) system present in a brain tumor-glioblastoma multiforme, GM, has emerged as a useful method to reduce malignant development. Using anti-gene anti-IGF-I technology (antisense, AS and triple helix, TH), applied in glioma cell culture established from GM biopsies induces the expression of B7 and MHC-I antigens in transfected cells (immunogenic cell tumor vaccines). After subcutaneous injection of vaccines, an immune response mediated by T CD8+ and T CD28+ lymphocytes was initiated, and followed by tumor regression. The GM patients treated classically by surgery and radiotherapy, while followed by immuno-gene therapy, have reached 21 - 24 months of median survival.

Keywords: Glioblastoma; Immuno-Gene Therapy; Anti-Gene IGFI

References

  1. Cancer moonshot blue ribbon panel report (2016).
  2. Anderson WF., et al. “The ADA human gene therapy clinical protocol: Points to consider response with clinical protocol”. Human Gene Therapy3 (1990): 331-362.
  3. Trojan J., et al. “Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense Insulin like Growth Factor I RNA”. Science 5091 (1993): 94-97.
  4. Townsend SE and Allison JP. “Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells”. Science5093 (1993): 368-370.
  5. Guo Y., et al. “Effective tumor vaccine generated by fusion of hepatoma cells with lymphocytes B cells”. Science 5146 (1994): 518-520.
  6. Trojan J. “Brain-from development to neoplasia and gene therapy solution”. Ed. Lambert Academic Publishers, Germany (2017/2018): 1-150.
  7. Pollak MN., et al. “Insulin-like growth factors and neoplasia”. Nature Review Cancer7 (2004): 505-518.
  8. Rubenstein J., et al. “Nonsense RNA: a tool for specifically inhibiting the expression of a gene in vivo”. Compte Rendu Academie de Science Paris III8 (1984): 271-274.
  9. Weintraub H., et al. “Antisense RNA as a molecular tool for genetic analysis”. Trends in Genetics1 (1985): 23-25.
  10. Dervan P. “Reagents for the site specific cleavage of megabase DNA”. Nature6390 (1992): 87-88.
  11. Hélène C. “Control of oncogene expression by antisense nucleic acid”. European Journal of Cancer11 (1994): 1721-1726.
  12. Quintero G., et al. “Glioblastoma-application of gene therapy during a quarter of century: Anti-gene IGF-I strategy”. Acta Scientific Cancer Biology1 (2020): 38-45.
  13. Shevelev A., et al. “Potential triple helix-mediated inhibition of IGF-I gene expression significantly reduces tumorigenicity of glioblastoma in an animal model”. Cancer Gene Therapy2 (1997): 105-112.
Citation: Jerzy Trojan., et al. “Glioblastoma and Successful Cancer Immuno-Gene Therapy”. EC Clinical and Medical Case Reports 3.5 (2020): 59-61.

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