Research Article
Volume 3 Issue 4 - 2020
New Therapies for the Treatment of Ataxic Cerebral Palsy Caused by Kernicterus
Aamir Jalal Al Mosawi*
Advisor in Pediatrics and Pediatric Psychiatry, Children Teaching Hospital of Baghdad Medical City and Head, Iraq Headquarter of Copernicus Scientists International Panel, Baghdad, Iraq
*Corresponding Author: Aamir Jalal Al Mosawi, Advisor in Pediatrics and Pediatric Psychiatry, Children Teaching Hospital of Baghdad Medical City and Head, Iraq Headquarter of Copernicus Scientists International Panel, Baghdad, Iraq.
Received: January 04, 2020; Published: March 18, 2020




Abstract

Background: Early during life, excessive hyperbilirubinemia results in accumulation of bilirubin in the grey matter of the brain causing neurotoxicity with damage of neurons by apoptosis and necrosis leading to irreversible brain damage called kernicterus and bilirubin encephalopathy. Clinical manifestations of kernicterus include ataxic form of cerebral palsy. We have previously reported the novel use of cerebrolysin and citicoline in the treatment of a girl with kernicterus who experience improvement without the occurrence of side effects. The aim of this paper is to describe the beneficial use of cerebrolysin and citicoline a boy with ataxic form of cerebral palsy caused by kernicterus.

Patients and Methods: The treatment of a two-year old boy with ataxic cerebral palsy caused by kernicterus associated with delayed speech is described. Before treatment, the boy had difficulty in sitting without support for more than few seconds and was holding the chair to keep his position. He could stand holding furniture and could stand alone for seconds but was unable to take any further step without support. The boy was treated with intramuscular cerebrolysin 3 ml every other day (15 doses), and intramuscular citicoline 3 ml (375 mg) every other day. 

Results: After treatment, the boy was able to sit without support for long time and could stand without holding anything for long time.

Conclusion: The use of intramuscular cerebrolysin and citicoline was associated with some improvement and was found to be beneficial without the occurrence of any side effects. 

Keywords: Ataxic Cerebral Palsy; Kernicterus; Treatment; Cerebrolysin; Citicoline

References

  1. AI-Mosawi AJ. “A novel therapeutic approach for the neurological complications of kernicterus”. 1st edition, Saarbrücken; LAP Lambert Academic Publishing (2018).
  2. Al-Mosawi AJ. “The novel use of cerebrolysin and citicoline in the treatment of kernicterus”. Journal of Neurology and Brain Disorders 3.1 (2019): 208-212.
  3. Al-Mosawi AJ. “A new therapeutic approach for the treatment of brain atrophy”. 1st edition, Saarbrücken; LAP Lambert Academic Publishing (2017).
  4. Al-Mosawi AJ. “A novel therapeutic approach for idiopathic mental retardation”. 1st edition, Saarbrücken; LAP Lambert Academic Publishing (2018).
  5. Al-Mosawi AJ. “New therapies for the treatment of spastic cerebral palsy”. 1st edition, Saarbrücken; LAP Lambert Academic Publishing (2019). 
  6. Al-Mosawi AJ. “New Therapies for the treatment of spastic cerebral palsy”. Medical Journal of Clinical Trials and Case Studies 3.2 (2019): 000209. 
  7. Al-Mosawi AJ. “A novel therapeutic approach for myelomeningocele”. 1st edition, Saarbrücken; LAP Lambert Academic Publishing (2018).
  8. Al-Mosawi AJ. “New medical therapies for the treatment of myelomeningocele”. Surgical Medicine Open Access Journal 2.4 (2019): 1-4.
  9. Al-Mosawi AJ. “The use of piracetam and cerebrolysin in the treatment of agenesis of corpus callosum with colpocephaly”. EC Clinical and Medical Case Reports 3.1 (2020): 01-05.
  10. Al-Mosawi AJ. “Citicoline research progress”. 1st edition., Saarbrücken; LAP Lambert Academic Publishing (2019). 
  11. Al-Mosawi AJ. “A new therapeutic approach for pervasive developmental disorders”. 1st edition., Saarbrücken; LAP Lambert Academic Publishing (2018).
  12. Al-Mosawi AJ. “The use of cerebrolysin and citicoline in autism and Asperger syndrome”. Journal of Bio Innovation 8.1 (2019): 99-108.
  13. Al-Mosawi AJ. “New therapies for Rett syndrome”. Journal of Bio Innovation 8.3 (2019): 301-307. 
  14. Al-Mosawi AJ. “A novel therapy for pediatric juvenile spinal muscular atrophy”. 1st edition, Saarbrücken; LAP Lambert Academic Publishing (2018).
  15. Al-Mosawi AJ. “A novel therapy for pediatric Charcot Marie Tooth disease”. 1st editoon, Saarbrücken; LAP Lambert Academic Publishing (2018).
  16. Al-Mosawi AJ. “The etiology of mental retardation in Iraqi children”. SunKrist Journal of Neonatology and Pediatrics 1.1 (2019): 1-9.
Citation: Aamir Jalal Al Mosawi. “New Therapies for the Treatment of Ataxic Cerebral Palsy Caused by Kernicterus”. EC Clinical and Medical Case Reports 3.4 (2020): 26-31.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


March Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the March issue of respective journals and can be viewed in the current issue pages.

Submission Deadline for April Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the May issue of respective journals. Submissions are accepted on/before April 14, 2020.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk