Volume 3 Issue 3 - 2020
Innovating Applications with Trans-Thoracic Echocardiography in Goal Directed Fluid and Hemodynamic Therapy in Children
Claudine Kumba1-4*
1Department of Pediatric Anesthesia and Critical Care, Necker Enfants Malades University Hospital, Assistance Publique Hôpitaux de Paris, APHP, University of Paris, Paris, France
2Ecole Doctorale 563 Médicament-Toxicologie-Chimie-Imageries (MTCI), Université de Paris, Paris, France
*Corresponding Author: Claudine Kumba, Department of Pediatric Anesthesia and Critical Care, Necker Enfants Malades University Hospital, Assistance Publique Hôpitaux de Paris, APHP, University of Paris, Paris and Ecole Doctorale 563 Médicaments-Toxicologie-Chimie-Imageries (MTCI), Université de Paris, Paris, France.
Received: January 31, 2020; Published: February 12, 2020


Background: Recent trial protocols with trans-thoracic echocardiography have been elaborated in children to guide fluid and hemodynamic therapy. This Editorial describes the development and perspectives of these trials.

Objectives: Objectives of this Editorial is to update the latest development of new trials with trans-thoracic echocardiography for goal directed fluid and hemodynamic therapy in children.

Methods: Mini-review and summary of the studies in development.

Results and Conclusion: These trials will enlight and clarify the impact of goal directed fluid and hemodynamic therapy with echocardiographic indices on postoperative outcome in the pediatric surgical population.

Keywords: Trans-thoracic Echocardiography; Pediatric Surgery; Pediatric Anesthesia and Critical Care; Postoperative Outcome


  1. Kumba C., et al. “Transfusion and Morbi-Mortality Factors: An Observational Descriptive Retrospective Pediatric Cohort Study”. Journal of Anesthesia and Critical Care: Open Access 8.4 (2017): 00315. 
  2. Chong M., et al. “Does doal-directed haemodynamic and fluid therapy improve peri-operative outcomes ? A systematic review and meta-analysis”. European Journal of Anaesthesiology 35.7 (2018): 469-483.
  3. Favia I., et al. “Predicting Fluid Responsiveness in Children Undergoing Cardiac Surgery After Cardiopulmonary Bypass”. Pediatric Cardiology 38 (2017): 787-793.
  4. Desgranges FP., et al. “Respiratory Variation in Aortic Blood Flow Peak Velocity to Predict Fluid Responsivenes in Mechanically Ventilated Children: A Sytematic Review and Meta-Analysis”. Pediatric Anesthesia 26 (2016): 37-47.
  5. Morparia KG., et al. “Respiratory Variation in Peak Aortic Accurately Predicts Fluid Responsiveness in Children Undergoing Neurosurgery Under General Anesthesia”. Journal of Clinical Monitoring and Computing 201.32 (2001): 221-226.
  6. Pereira de Souza Neto E., et al. “Predicting Fluid Responsiveness in Mechanically Ventilated Children Under General Anaesthesia Using Dynamic Parameters and Transthoracic Echocardiography”. British Journal of Anaesthesia 106.6 (2011): 856-864.
  7. Klimczak C. “Echocardiographie Clinique”. 6th Edition, Paris, Elsevier Masson (2010): 32-34.
  8. Solinski A., et al. “Centile Curves for Velocity-Time Integral Times Heart Rates as a Function of Ventricular Length: The Use of Minute Distance Is Advantageous to Enhance Clinical Reliability in Children”. Journal of the American Society of Echocardiography 31 (2018): 105-112.
  9. Kumba C., et al. “Perioperative Echocardiographic Hemodynamic Parameters and Postoperative Outcome in Pediatric Congenital Heart Disease: A Descriptive Observational Prospective Pilot Study Protocol”. International Journal of Pediatrics Care 5 (2019): 160. 
  10. Kumba C and Tréluyer JM. “Perioperative Echocardiographic Hemodynamic Parameters and Postoperative Outcome in Pediatric Surgical Patients: A Descriptive Observational Prospective Pilot Study Protocol”. Research in Pediatrics and Neonatology Journal 4.1 (2019).
  11. Kumba C. “Trans-thoracic Echocardiographic Aortic Blood Flow Peak Velocity Variation, Distance Minute, Aortic Velocity Time Integral and Postoperative Outcome in Pediatric Surgical Patients-An Observational Pilot Study Protocol” (2020). 
  12. Kumba C., et al. “Perioperative Goal Directed Fluid and Hemodynamic Therapy with Echocardiography in Pediatric Congenital Heart Disease: A Study Protocol”. EC Paediatrics 8.12 (2019): 1-7.
  13. Kumba C and Tréluyer J. “Perioperative Goal Directed Fluid and Hemodynamic Therapy with Echocardiography in Children: A Study Protocol”. Research in Pediatrics and Neonatology Journal 4.2 (2019). 
  14. Kumba C. “Goal Directed Fluid and Hemodynamic Therapy with Trans-Thoracic Echocardiographic Aortic Blood Flow Peak Velocity Variation in Children and Postoperative Outcome: A Randomized Controlled Trial Protocol” (2020).
  15. Kumba C and Mélot C. “The Era of Goal Directed Therapies in Paediatric Anaesthesia and Critical Care”. EC Emergency Medicine and Critical Care 3.5 (2019): 306-309.
  16. Kumba C. “Do goal directed therapies improve postoperative outcome in children? (Perioperative goal directed fluid and hemodynamic therapy Transfusion goal directed therapy using viscoelastic methods and enhanced recovery after surgery and postoperative outcome): A study research protocol”. Acta Scientific Paediatrics 2.7 (2019): 17-19. 
  17. Kumba C. “Future evolution of intraoperative goal directed fluid and hemodynamic therapy in Children”. Advances in Pediatric Research 6 (2019): 29. 
  18. Kumba C., et al. “A Systematic Review and Meta-Analysis of Intraoperative Goal Directed Fluid and Haemodynamic Therapy in Children and Postoperative Outcome”. Journal of Emergency Medicine and Critical Care 5.1 (2019): 9. 
Citation: Claudine Kumba. “Innovating Applications with Trans-Thoracic Echocardiography in Goal Directed Fluid and Hemodynamic Therapy in Children”. EC Clinical and Medical Case Reports 3.3 (2020): 01-03.

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