Research Article
Volume 3 Issue 3 - 2020
The Efficacy of Hyperbaric Oxygen Therapy Versus Low Level Laser Therapy on Transcutaneous Oxygen Saturation for Venous Leg Ulcer
Siham M Fahmy1* and Yasser Elsayed2
1PhD in Physical Therapy for Surgery and Head of HBO and Foot Care Center at Kobri El Koba Military Medical Collection, Egypt
2Vice President of the Military Medical Academy, Cairo, Egypt
*Corresponding Author: Siham M Fahmy, PhD in Physical Therapy for Surgery and Head of HBO and Foot Care Center at Kobri El Koba Military Medical Collection, Egypt.
Received: December 26, 2019; Published: February 05, 2020


Background and Purpose: Venous ulcers are most common kind of chronic leg ulcers represents about 60 to 80% and considered the main cause of morbidity. Hyperbaric Oxygen therapy recorded significant improvement of wound healing and t issue repair at all stages.

Wound healing was one of the first areas in which the effect of Low Level Laser Therapy was investigated; laser irradiation is releasing of vascular endothelial growth factor (VEGF) which stimulates not only angiogenesis but also endothelial cell growth.

This study investigated the effect of HBOT versus LLLT on transcutaneous oxygen saturation (TcPO2) at the margin of chronic leg ulcers.

Patients and Methods: Forty patients with chronic venous ulcers suffering for more than 6 weeks without improvement, there ages ranged from 20 - 60 were included in the present study. Those patients were classified randomly into 2 groups of equal number, 20 patients for each group. The first group was treated with Low Level Laser Therapy by Scanner Infrared diode laser with wavelengths 880 and 950 nm - Energy density 5 J/cm2 - time of session depended on ulcer parameters (once daily for repeated 10 days) and the second group was treated with Hyperbaric Oxygen Therapy by Hyperbaric oxygen chamber at pressure 1.5 Bar, time of session 90 minutes with 60 minutes breathing 100% pure oxygen through the individual mask (once daily for repeated 10 sessions). 

Results: Hyperbaric oxygen therapy get the higher mean value recorded 1.884 ± 0.506. While the mean value of low level laser therapy recorded 0.265 ± 0.529.

Conclusion: Improving the microcirculation and increasing transcutaneous oxygen saturation to the ulcer region with hyperbaric oxygen therapy was more than low level diode laser.

Keywords: Transcutaneous; Oxygen Saturation; Hyperbaric; Oxygen Therapy; Low Level Laser; Diode Laser


  1. Vasudevan B. “Pathophysiology and classification of leg ulcers”. Indian Dermatology Online Journal 5.3 (2014): 366-370.
  2. Millan BS., et al. “Venous Ulcers: Diagnosis and Treatment”. American Family Physician 100.5 (2019): 298-305.
  3. Kulcke A. “Principles and contexts of tissue oxygenation imaging (HSI technology) and transcutaneous oxygen measurement in tissue (TcPO2)” (2019). 
  4. Vincent E., et al. “Reference value of transcutaneous oxygen measurement in diabetic patients compared with nondiabetic patients”. Journal of Vascular Surgery 48.2 (2008): 382-388.
  5. Dunnwald T., et al. “Combined Hyperbaric Oxygen Partial Pressure at 1.4 Bar with Infrared Radiation: A Useful Tool To Improve Tissue Hypoxemia?” Medical Science Monitor 24 (2018): 4009-4019.
  6. Latham E., et al. “Hyperbaric oxygen therapy”. eMedicine. Medscape (2009). 
  7. Niinikoski JH. “Clinical hyperbaric oxygen therapy, wound perfusion, and transcutaneous oximetry”. World Journal of Surgery 28.3 (2004): 307-311.
  8. Bhutani S and Vishwanath G. “Hyperbaric oxygen and wound healing”. Indian Journal of Plastic Surgery 45.2 (2012): 316-324.
  9. Ramos FS. “The effects of transcutaneous low-level laser therapy on the skin healing process: an experimental model”. Lasers in Medical Science 33.5 (2018): 967-976.
  10. Fiorio FB. “Photobiomodulation therapy action in wound repair skin induced in aged rats old: time course of biomarkers inflammatory and repair”. Lasers in Medical Science 32.8 (2017): 1769-1782.
Citation: Siham M Fahmy and Yasser Elsayed. “The Efficacy of Hyperbaric Oxygen Therapy Versus Low Level Laser Therapy on Transcutaneous Oxygen Saturation for Venous Leg Ulcer”. EC Clinical and Medical Case Reports 3.3 (2020): 01-05.

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