Case Report
Volume 3 Issue 2 - 2020
A Case of Early Interstitial Abnormalities and Obstructive Sleep Apnea
Marica Tina Maccarone1, Alessandro Corazzini2, Alberto D’Alleva3, Giacomo Zuccarini4, Pierpaolo Prosperi4, Antonietta Esposito4, Antonella Spacone4*
1Radiology Unit, Hospital “Santo Spirito”, Pescara, Italy
2Cardiology Unit, Hospital “Santo Spirito”, Pescara, Italy
3Interventional Cardiology Unit, Hospital “Santo Spirito”, Pescara, Italy
4Respiratory Medicine Unit, Hospital “Santo Spirito”, Pescara, Italy
*Corresponding Author: Antonella Spacone, Respiratory Medicine Unit, Hospital “Santo Spirito”, Pescara, Italy.
Received: January 27, 2019; Published: January 31, 2020


Introduction: Interstitial lung abnormalities (ILA) have been associated with early and mild forms of pulmonary fibrosis and is defined as a precursor stage of idiopathic pulmonary fibrosis (IPF).

ILAs are linked to with age environmental and genetic risk factors, and pulmonary symptoms of IPF. Identifying patients with IPF at the earliest opportunity remains one of the most urgent challenges in the effective management of this disease. 

IPF is associated with obstructive sleep apnea (OSA) and several studies suggest that initiating treatment in the early stages of pulmonary fibrosis will slow the decline in pulmonary function and prevent early mortality. We describe a case report of a patient with ILA and OSA.

Case Report: CZ, a 71 year- old obese male and ex asphalterist, underwent a pulmonary examination on suspicion of OSA. The pneumological examination revealed digital hippocratism and fine Velcro-like crackles at the bases bilaterally. A computed tomography (CT) scan demonstrated the presence of ILA. He was subjected to cryobiopsy for diagnostic completion: the biopsy specimens were examined for evidence of usual interstitial pneumonia (UIP) pattern; thus, the definite diagnosis on establishment of a consensus by a multidisciplinary team was of IPF. The suspicion of OSA was confirmed by nocturnal cardiorespiratory monitoring: the patient had a severe positional OSA and we has treated with positional therapy, and antifibrotic drug.

Conclusion: This clinical case underscores the importance of the early identification of IPF that is obscured by the features of ILA. An earlier diagnosis of IPF is needed for timely treatment and, potentially, improves the long-term clinical outcomes of this progressive and ultimately fatal disease. All associated comorbidities in IPF must be recognized and treated early, such as OSA.

Keywords: Interstitial Lung Abnormalities; Obstructive Sleep Apnea; Idiopathic Pulmonary Fibrosis


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Citation: Antonella Spacone., et al. “A Case of Early Interstitial Abnormalities and Obstructive Sleep Apnea”. EC Clinical and Medical Case Reports 3.2 (2020): 01-06.

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