Abstract

Purpose of the Study: Study the effectiveness of oral mucositis (OM) prevention by the stimulation of white cells phagocytic activity and activation of endogenous keratinocyte growth factor production by laser blood irradiation method (LBI).

Materials and Methods: The current study includes 470 children with malignant neoplasms receiving high-dose chemotherapy. All patients are divided into 3 groups, depending on the type of oral mucositis prevention. In group #1 of this study are included 220 children who were receiving the OM prevention with medication.

Group #2 of children is represented by 140 children. The OM prevention in this group was carried out by methods of local laser therapy. Laser radiation was applied to the areas of the oral cavity, where OM is most often developed.

The basis of this study are 110 patients of 3 groups, whom for the first time in the world prophylaxis of OM was carried out by laser irradiation of blood. 29 patients have already passed the high-dose polychemotherapy complicated by OM development. In the study we applied the method of identification of the white cells phagocytic activity state using the test sheet of latex microparticles. The study was performed before high-dose polychemotherapy, after LBI and after chemotherapy. Blood exposure to laser irradiation was made by placing the emitter on skin above the large vessels: areas of carotid arteries and veins, cubital, subclavian or popliteal.

Results: LBI technique was used in 260 courses of high-dose polychemotherapy. Stimulation of phagocytes by LBI method showed that application of this method before chemotherapy leads to the positive result in all cases. OM developed in only 1 child, which amounted to 0.9%.

Conclusion: Blood test for white cells phagocytic activity gives a chance to determine the actual readiness of the body to resist infections. If it was impossible to predict oral mucositis development before, now implementation of white cells phagocytic activity determination method improves the effectiveness of such prognosis. Thus, first in the world, all results that we obtained became possible only due to implementation of the white cells phagocytic activity test and stimulation of the white cells phagocytic activity and activation of the endogenous keratinocyte growth factor production by laser blood irradiation method.

Keywords: Pediatric Oncology; Oral Mucositis; Laser Irradiation of Blood

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