Abstract

Human skeleton represents a living tissue which carries out both structural as well as metabolic functions. Besides being the largest preservation house for calcium as well as rest of the essential ions but further works as a depot for toxic chemicals challenges received by body right through life. Modeling of skeleton gets initiated right at conception, followed by throughout life with continuous modeling for adopting its shape as well as strength based on bodily requirements. As human being grows, just like rest of the bodily tissues, bones as well get affected secondary to aging with this life long event loses both strength along with viability. Lot of genetic along with environmental factors participate in its development strength as well as decline, besides hormonal factors, and certain RNA’s. Earlier we had reviewed how to prevent osteoporotic fracture in perimenopausal women. Here we conducted a systematic review on advances in our knowledge of bone development, regeneration utilizing pubmed, google scholar, web of science, embase utilizing MeSH terms like Human skeleton; development; regeneration; Modeling; bones; osteoblast; osteocytes; chondrocytes; minerals; nutrition; miRNA from 1995 - 2020 till date in October. We found a total of 6700 articles, out of which we utilized 66 articles for this review. No meta-analysis was performed. Here we describe the anatomy and development of bone right through life at different stages of life in both sexes.

Keywords: Human Skeleton; Modeling; Bones; Osteoblast; Osteocytes; Chondrocytes; Development

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