Abstract

This research is meant to evaluate the effect of Parkia biglobosa aqueous seed extract on the histology of the kidney of adult Wistar rat, Twenty-one [21] adult Wistar rats weighing about 90 - 120g were use for this research work and were split into three pairs of seven animals each. The control group were administered with normal rat feed and water, the low dose group were administered with (300 mg/kgBwt) of Parkia biglobosa extract and the high dose group were administered with (500 mg/kgBwt) of Parkia biglobosa. All extract was given daily, orally for thirty one (31) days. Twenty-four hours after the last administration the animals in all groups were sacrifice using cervical dislocation. And the kidneys were removed for histological tissues processing using Hematoxylin and Eosin (H&E) stains. Result of the study showed a significant (p < 0.05) increase in final body weight of all the animals in contrast to their initial body weight. Histological observation of control group shows normal glomerulus (G) with tubules (T) appearing normal, sections from the kidney of the low and high dose treated animals showed mild glomerular sclerosis and tubular necrosis, and so it can be concluded that the administration of aqueous seed extract of Parkia biglobosa is relatively not toxic to wistar rat when administered at low dose and caution should be taken in higher quantity.

Keyword: Glomerulus; Sclerosis; Tubular Necrosis; Kidney; Hematoxylin and Eosin

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