Review Article
Volume 3 Issue 7 - 2020
Intestinal Immune System in the Regulation of Obesity and Metabolic Syndrome-Therapeutic Implications-A Systematic Review
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India
*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.
Received: February 17, 2020; Published: June 30, 20200




Abstract

Obesity has reached epidemic proportions. WHO cites that > 1.9 billion people are overweight of which 600 million are obese. Obesity is associated with numerous complications like insulin resistance (IR), Type 2 Diabetes Mellitus (T2DM), along with increased numbers of cancers, cardiovascular and autoimmune diseases among others. Chronic low grade inflammation accompanies obesity. More and more data points to the involvement of intestinal immune system with inflammation of other metabolic tissues like liver and visceral Adipose tissue (VAT) also getting involved. Obesity leads to Altered intestinal immunity, which correlates with gut microbiota changes, changes in intestinal barrier function, innate and adaptive immunity residing in the gut along with oral tolerance to luminal antigens. Thus we conducted a systemic review of literature using Pubmed search engine using key MeSH terms like obesity; intestinal immunity; innate immune system, both innate and cellular; intestinal adaptive immune response and oral tolerance We found a total of 398 articles out of which we selected 120 articles for this review. No meta-analysis was done. Based on this research novel avenues get opened up for attempting to treat obesity and systemic disorders metabolic diseases related to obesity.

Keywords: Obesity; Chronic Low Grade Inflammation; Intestinal Cellular and Adaptive Immunity; Intestinal Barrier Function; Changes in Intestinal Permeability; Lipopolysaccharides; Metabolic Endotoxaemia

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Citation: Kulvinder Kochar Kaur., et al. “Intestinal Immune System in the Regulation of Obesity and Metabolic Syndrome-Therapeutic Implications-A Systematic Review”. EC Clinical and Experimental Anatomy 3.7 (2020): 07-22.

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