Review Article
Volume 3 Issue 6 - 2020
Radiographic Anatomy in Parkinson Disease - A Mini Review in the Service of Early Diagnosis
Yasmin Mokhtari Garkani1 and Evangelos Mavrommatis2*
1Department of Biomedical Science- Radiology and Radiotherapy, School of Health and Caring Sciences, University of Western Attica, Athens, Greece
2Department of Anatomy, Medical School, National and Kapodistrian University of Athens, Athens, Greece
*Corresponding Author: Evangelos Mavrommatis, Department of Anatomy, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Received: February 29, 2019; Published: May 28, 2020


Background: Parkinson's disease (PD) is a neurodegenerative disorder affecting the autonomic, limbic and somatomotor system. The most common damages in PD are neocortical, mesolimbic and tuberoinfundibular. Non-motor features include depression, urinary incontinence, hypotension, anosmia, erectile dysfunction, constipation, sleep disorders, and fatigue. However, this cluster of symptoms is rarely used to diagnose PD at an early stage, as differential diagnosis seems rather difficult. The etiology of PD remains unclear and most cases are sporadic. Nevertheless, genetic mutations of at least 20 proteins such as TDP-43, amyloid-β alpha-synuclein at S129, have been demonstrated to cause inherited forms of the disease. The process of neurodegeneration in PD begins long before the onset of clinical symptoms and lacks of specific clinical phenotype, resulting in untimely diagnosis and treatment. Imaging studies such as DAT-SPECT, PET-CT and MRI establish their true value in diagnosing prodromal neurodegeneration. Method: This bibliographic review aims to summarize research findings regarding the value of various imaging methods, in the diagnostic work-up of PD. Manuscripts included in the databases PubMed/Medline and Scopus were included in the review.

Results: PET and SPECT ligands can demonstrate the presence of terminal dopamine dysfunction in early and preclinical disease. Moreover, MRI imaging has enhanced diagnostic accuracy in the differential diagnosis of neurodegenerative parkinsonism. PD imaging detects a possible alternative diagnoses, while its landmark includes the identification of early, new-onset, and even prodromal PD and may alter the therapeutic approach.

Conclusion: Imaging modalities present an essential role in PD early detection and diagnosis.

Keywords: DAT-SPECT; PET-CT; MRI; Parkinsonism; Neuroimaging


  1. Junqueira SC., et al. "Post-translational modifications of Parkinson's disease-related proteins: Phosphorylation, SUMOylation and Ubiquitination". Biochimica et Biophysica Acta - Molecular Basis of Disease 8 (2019): 2001-2007.
  2. Moghaddam HS., et al. "Association Between Peripheral Inflammation and DATSCAN Data of the Striatal Nuclei in Different Motor Subtypes of Parkinson". Frontiers in Neurology 9 (2018): 234.
  3. Kwon SD., et al. "Comparison of the Performances of 18F-FP-CIT Brain PET/MR and Simultaneous PET/CT: a Preliminary Study". Nuclear Medicine and Molecular Imaging 3 (2016): 219-227.
  4. Rahmim A., et al. "Improved prediction of outcome in Parkinson's disease using radiomics analysis of longitudinal DAT SPECT images". NeuroImage: Clinical 16 (2017): 539-544.
  5. Brooks DJ. "Parkinson's disease: diagnosis". Parkinsonism and Related Disorders 1 (2012): S31-S33.
  6. Kägi G., et al. "The role of DAT-SPECT in movement disorders". Journal of Neurology, Neurosurgery, and Psychiatry 1 (2010): 5-12.
  7. Scherfler C., et al. "Role of DAT-SPECT in the diagnostic work up of parkinsonism". Movement Disorders 9 (2007): 1229-1238.
  8. Bajaj N., et al. "Clinical utility of dopamine transporter single photon emission CT (DaT-SPECT) with (123I) ioflupane in diagnosis of parkinsonian syndromes". Journal of Neurology, Neurosurgery, and Psychiatry 11 (2013): 1288-1295.
  9. Mirpour S., et al. "Impact of DAT-SPECT on Management of Patients Suspected of Parkinsonism". Clinical Nuclear Medicine 10 (2018): 710-714.
  10. Park E. "A new era of clinical dopamine transporter imaging using 123I-FP-CIT". Journal of Nuclear Medicine Technology 4 (2012): 222-228.
  11. Ba F and Martin WR. "Dopamine transporter imaging as a diagnostic tool for parkinsonism and related disorders in clinical practice". Parkinsonism and Related Disorders 2 (2015): 87-94.
  12. Broski SM., et al. "Structural and functional imaging in parkinsonian syndromes". RadioGraphics 5 (2014): 1273-1292.
  13. Liu FT., et al. "Clinical, Dopaminergic, and Metabolic Correlations in Parkinson Disease: A Dual-Tracer PET Study". Clinical Nuclear Medicine 8 (2018): 562-571.
  14. Jin R., et al. "Validation of abnormal glucose metabolism associated with Parkinson's disease in Chinese participants based on 18F-fluorodeoxyglucose positron emission tomography imaging". Neuropsychiatric Disease and Treatment 14 (2018): 1981-1989.
  15. Jin S., et al. "Differential Diagnosis of Parkinsonism Using Dual-Phase F-18 FP-CIT PET Imaging". Nuclear Medicine and Molecular Imaging1 (2013): 44-51.
  16. Chen Z., et al. "Synthesis and Preliminary Evaluation of [11 C]GNE-1023 as a Potent PET Probe for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2) in Parkinson's Disease". ChemMedChem 17 (2019): 1580-1585.
  17. Pérez-Lohman C., et al. "Diagnostic Utility of [11C] DTBZ Positron Emission Tomography In Clinically Uncertain Parkinsonism: Experience of a Single Tertiary Center". Revista de Investigación Clínica 6 (2018): 285-290.
  18. Berman SB and Miller-Patterson C. "PD and DLB: Brain imaging in Parkinson's disease and dementia with Lewy bodies". Progress in Molecular Biology and Translational Science 165 (2019): 167-185.
  19. Heim B., et al. "Magnetic resonance imaging for the diagnosis of Parkinson’s disease". Journal of Neural Transmission 8 (2017): 915-964.
  20. Meijer FJA., et al. "Conventional 3T brain MRI and diffusion tensor imaging in the diagnostic workup of early stage parkinsonism". Neuroradiology7 (2015): 655-669.
  21. Meijer FJ., et al. "Susceptibility-weighted imaging improves the diagnostic accuracy of 3T brain MRI in the work-up of parkinsonism". American Journal of Neuroradiology 3 (2015): 454-460.
  22. Rizzo G., et al. "Brain MR Contribution to the Differential Diagnosis of Parkinsonian Syndromes: An Update". Parkinsonism and Related Disorders 1 (2012): S31-S33.
  23. Meijer FJ., et al. "Update on diffusion MRI in Parkinson's disease and atypical parkinsonism". Journal of the Neurological Sciences 1-2 (2013): 21-29.
  24. Honkanen E., et al. "No link between striatal dopaminergic axons and dopamine transporter imaging in Parkinson's disease". Movement Disorders 10 (2019): 1562-1566.
Citation: Yasmin Mokhtari Garkani and Evangelos Mavrommatis. “Radiographic Anatomy in Parkinson Disease - A Mini Review in the Service of Early Diagnosis". EC Clinical and Experimental Anatomy 3.6 (2020): 06-11.

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