Research Article
Volume 3 Issue 5 - 2020
A Comparison Study on Contrast Agents between Lead Oxide and Iopamidol Using for Three-dimensional Reconstruction of Blood Vessels in Isolated Placenta
Youjiang Xu1, Congqing Li1, Ling Xu2, Huan Li2, Yu Zhang1, Bing Wei1 and Wenyan Wang1*
1Department of Obstetrics Gynecology, The Second Hospital of Anhui Medical University, Hefei Anhui, China
2Department of Radiology, The Second Hospital of Anhui Medical University, Hefei Anhui, China
*Corresponding Author: Wenyan Wang, Department of Obstetrics Gynecology, The Second Hospital of Anhui Medical University, Hefei Anhui, China.
Received: March 16, 2020; Published: April 13, 2020


Background: The aim of this study was to investigate the image for three-dimensional reconstruction of blood vessels in isolated placentas after using lead oxide or iopamidol as contrast agent.

Methods: A prospective study was conducted within 20 normal human placentas donated from puerperal without complications during pregnancy in the Second Hospital of Anhui Medical University from December 2015 to February 2016. The placentas were divided into two groups and each group had 10 samples. Lead oxide or iopamidol was injected into both umbilical arteries and veins separately. Then CT scan was performed and post processing the images of placental blood vessels was completed using three-dimensional reconstruction technique. Placental volume, vascular volume and vessel diameters of different branches were measured. Data were analyzed between groups using Student’s t-test.

Results: The images of the primary and secondary vascular branches of the placentas using lead oxide as contrast agent were in the strong three-dimensional sense without obvious artifacts, while the tertiary and fourth branches in the images looked blurred, and the microvascular of the placental lobular in the images looked sparse. On the contrary, the primary and secondary branches in the images using iopamidol as contrast agent were not so strong three-dimensional sense, while the tertiary and fourth vascular branches’ perfusion had less peripheral vascular artifacts compared with the lead oxide group. The value of placental volume and vascular volume between the lead oxide and iopamidol groups had no significant difference (P > 0.05). The value of the diameter in the primary and secondary branches in the lead oxide group were significantly greater than that in the iopamidol group, while the value of the diameter in the tertiary and fourth branches were obvious smaller than that in the iopamidol group (P < 0.05).

Conclusion: Lead oxide is more suitable for displaying the three-dimensional reconstruction images in primary and secondary vascular branches of the placentas, while iopamidol is more suitable for displaying the three-dimensional reconstruction images in the third and fourth branches. Quantitative measurement of the three-dimensional reconstruction blood vessels may be used as a basic measurement during placental vascular research.

Keywords: Lead Oxide; Iopamidol; Placenta; Three-Dimensional Reconstruction; Contrast Agent


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Citation: Wenyan Wang., et al. "A Comparison Study on Contrast Agents between Lead Oxide and Iopamidol Using for Three-dimensional Reconstruction of Blood Vessels in Isolated Placenta”. EC Clinical and Experimental Anatomy 3.5 (2020): 26-32.

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