Research Article
Volume 3 Issue 3 - 2020
Tomographic Morphometry of the Magnum Foramen during Postnatal Development: Preliminary Results
Cullari Matias Leonardo1*, Lefty Luke1, Vallejo Azar Mariana2, Jaimovich Sebastian2, Gonzalez Paula2 and Bendersky Mariana1
1Laboratory of Living Anatomy (UBACyT), III Chair of Normal Anatomy, Faculty of Medicine, University of Buenos Aires, Argentina
2Biological Anthropology, National University of La Plata, CONICET, Argentina
*Corresponding Author:Cullari Matias Leonardo, Laboratory of Living Anatomy (UBACyT), III Chair of Normal Anatomy, Faculty of Medicine, University of Buenos Aires, Argentina.
Received: January 27, 2020; Published: February 18, 2020


Introduction: The foramen magnum (FM) is an anatomical structure located in the posterior fossa of the skull. This foramen becomes relevant in compressive syndromes of the central nervous system, which compromised the neuronal function and circulatory failure. The purpose of this study is to determine the morphometric values of the foramen magnum in studies by image and its relationship with the sex, ethnicity and pre- and post-natal history, being the first of its kind in our region.

Material and Method: This are an observational, cross-sectional and retrospective study. We analyzed 152 images of computed tomography of individuals (0 - 4 years old) of both sexes that did not present pathologies that affect the morphology of the skull. We analyzed the CT obtained from the year 2013 onwards. These images are part of the files of the Service of Neuroimaging Studies of the Pediatric Hospital S.A.M.I.C.; “Prof. Dr. Juan P. Garrahan", City of Buenos Aires. Methods were used based on morphometry of the linear measurements, angles and distances, obtaining a total of four measures. An AGFA software was used for image processing, getting the length of the foramen magnum, the transverse diameter, its area and shape. 

Results: 82 of the subjects were boys and 70 girls. The mean length of the FM increases gradually, being 28,43 mm at birth and 33,95 at age 4, in the same way, the mean transverse diameter increases from 21,06 mm at birth to 28,83 mm at age 4. The FM area grows from 453,63 mm2 at birth to 718,28 mm2 at age 4. The predominant shape of the foramen magnum in both sexes was pentagonal.

Conclusion: There are significant differences in longitude and area of the FM between men and women, being higher in males. It was also observed an increase in the results concomitant with age. 

Keywords: Skull; Foramen Magnum; Children; Anthropometry; Variations


  1. Testut L and Latarjet A. “Tome First: Osteology, Treatise on Human Anatomy, 9th Edition”. Editorial Salvat, Barcelona (1954): 124-156.
  2. Smoker W. “Craniovertebral junction: normal anatomy, craniometry, and congenital anomalies”. Radiographics 14.2 (1994): 255-277. 
  3. Bernard S., et al. "The human occipital bone: review and update on its embryology and molecular development". Child's Nervous System 31.12 (2017): 2217-2223. 
  4. Blaser SI., et al. "Skull base development and craniosynostosis". Pediatric Radiology 45.3 (2015): 485-496. 
  5. Gruber P., et al. “Variability of human foramen magnum size”. The Anatomical Record 292.11 (2009): 1713-1719. 
  6. Kanodia G., et al. “Morphometric analysis of posterior fossa and foramen magnum”. Journal of Neurosciences in Rural Practice 3.3 (2012): 261. 
  7. Kumar A., et al. “Morphometric evaluation of foramen magnum in dry human skulls”. International Journal of Anatomy and Research 3.2 (2015): 1015-1023. 
  8. Murshed KA., et al. “Morphometric evaluation of the foramen magnum and variations in its shape: a study on computerized tomographic images of normal adults”. Turkish Journal of Medical Sciences 33.5 (2003): 301-306. 
  9. Téllez-Girón JR. “Anatomy and pathology of the craniovertebral junction”. Anales de Radiology México (2006). 
  10. Muralidhar P Shepur., et al. “Morphometric analysis of foramen magnum”. International Journal of Anatomy and Research 2.1 (2014): 249-255. 
  11. Sharma S., et al. “Morphometric Evaluation of the Foramen Magnum and Variation in its Shape and Size: A Study on Human Dried Skull”. International Journals of Medical and Health Research 3.3 (2015): 1399-1403. 
  12. Catalina-Herrera CJ. “Study of the anatomic metric values of the foramen magnum and its relation to sex”. Acta Anatomica 130.4 (1987): 344-347. 
  13. Espinoza, E., et al. “Tomographic morphometry of the magno foramen and its relationship with sex and Mapuche ethnicity”. Revista ANACEM 9.10 (2011): 24. 
  14. Barut N., et al. “Evaluation of the bony landmarks in trans condylar approach”. British Journal of Neurosurgery 23 (2009): 276-281. 
  15. Zimelewicz Oberman., et al. “Morphometry of the posterior cranial pit: Importance in retrocondile approaches”. Revista Argentina Anatomy 6.2 (2015): 87-92.
Citation: Cullari Matias Leonardo., et al. “Tomographic Morphometry of the Magnum Foramen during Postnatal Development: Preliminary Results". EC Clinical and Experimental Anatomy 3.3 (2020): 01-08.

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