Research Article
Volume 3 Issue 2 - 2020
New Challenges for Prospective Effects of Well-Established Regimens of Treatment with Separate LHRH Agonists: What about Serum Testosterone Level and Disease Progression?
Ayse Veyhurda Dikmen*
Consultant Urologist, Ankara, Turkey
*Corresponding Author:Ayse Veyhurda Dikmen, Consultant Urologist, Ankara, Turkey.
Received: December 23,2019; Published: January 28, 2020




Abstract

Introduction and Objective: Several modern urology clinics with known reputation in terms of prostate cancer treatment, are still fond of providing the patients with well-established regimens of treatment with LHRH agonists in cases of locally-advanced and metastatic prostate cancer. I aimed to investigate the prospective effects of treatment of locally advanced or metastatic prostate cancer with luteinising hormone-releasing hormone agonists (LHRH) on serum testosterone level and disease progression. It was a challenging question to find out which of the LHRH agonists decrease serum total testosterone to lower levels in men with locally advanced or metastatic prostate cancer and to determine whether being on a certain LHRH agonist (leuprolide acetate or goserelin acetate) for at least 6 months has a correlation with disease progression or not. 

Materials and Methods: Concentration of serum total testosterone was measured in the same sera for measurement of serum total prostate specific antigen (PSA) level. 140 patients on leuprolide acetate and 155 patients on goserelin acetate were included. The mean ages of the patients were 74.14 ± 8.53 and 74.64 ± 8.45 in leuprolide group and goserelin group, respectively. The level of castration was accepted as 50 ng/dl. 

Results: Concentration of serum total testosterone and serum PSA level were measured. The relation between the type of LHRH agonist used and the measured concentration of serum total testosterone was statistically significant (p = 0.008). 

Disease progression was detected in 54 and 63 of the patients in leuprolide treatment group and goserelin treatment group, respectively (p = 0,446). 

Conclusion: In our study, 94 patients, who had been diagnosed to have disease progression during follow-up, had a concentration of serum total testosterone less than 20 ng/dl and the remaining patients with disease progression had that of equal to or greater than 20 ng/dl. 160 of patients who had had no progression the concentration of serum total testosterone was measured less than 20 ng/dl (p = 0,091). No statistically significant association between spot concentration of serum total testosterone and progression in time during the treatment of locally advanced or metastatic prostate cancer with LHRH agonists. My study is essential since it has studied the concentration of serum total testosterone in randomly selected patients with prostate cancer within Turkish population.

Keywords: Prostate Cancer; Cancer; LHRH Agonist; Metastatic; Locally Advanced; Testosterone

Citation: Ayse Veyhurda Dikmen.“ New Challenges for Prospective Effects of Well-Established Regimens of Treatment with Separate LHRH Agonists: What about Serum Testosterone Level and Disease Progression?”. EC Clinical and Experimental Anatomy 3.2 (2020): 01-03.

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