Mini Review
Volume 6 Issue 10 - 2020
The Potential and Promising Application of Fullerenes in Pain Management and Anaesthesia
Nicholas A Kerna1*, John V Flores2,3, Kevin D Pruitt4, Uzoamaka Nwokorie5 and HIlary M Holets2,3
1SMC–Medical Research, Thailand
2Beverly Hills Wellness Surgical Institute, USA
3Orange Partners Surgicenter, USA
3Kemet Medical Consultants, USA
3University of Washington, USA
*Corresponding Author: Nicholas A Kerna, POB47 Phatphong, Suriwongse Road, Bangkok, Thailand 10500.
Received: September 08, 2020; Published: October 29, 2020




Abstract

Fullerene, a carbon-based material, is being beneficially applied in nanotechnology on a limited but expanding basis. Some advantages of fullerene are its ability to react with nucleophiles and undergo various chemical reactions, such as reduction, oxidation, hydrogenation and halogenation. Some disadvantages of fullerene are its susceptibility to degrade in the presence of light and oxygen and decompose due to a shift from the excited singlet state to an energetically lower triplet state. Also, fullerene’s hydrophobic and aggregate-forming characteristics are significantly challenging in its application in medicine. Nevertheless, fullerene has potential applications in managing neuropathic pain and anaesthesia. The stimulation of specific voltage-gated sodium channels results in pain disorders. Fullerene can block the channel pore, demonstrating fullerene’s potential in managing neuropathic pain. In conjunction with nanorobot technology, fullerene might act as an anaesthetic or analgaesic agent and a nanomaterial for dental robots. Pristine C60 is relatively less toxic than other variants of nanocarbons, and in many instances, shows biocompatibility in humans. However, the manufacturing process of experimental-grade nanocarbon onion-like fullerene materials can be inconsistent (even within the same batch). Thus, performing reliable assessments and reproducible studies of their biological benefits, biocompatibility, and potential toxicity are are problematic

Keywords: Allotrope; Anaesthesia; Analgaesic; Buckyball; Fullerene; Isoform hNav1.7

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Citation: Kerna NA, Flores JV, Pruitt KD, Nwokorie U, Holets H. The Potential and Promising Application of Fullerenes in Pain Management and Anaesthesia. EC Anaesthesia. 2020 Sep 8; 6.11: 14-18.

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