Review Article
Volume 6 Issue 11- 2020
Pilot Validation of Early Predictors for Neonatal Sepsis
Rais Kh Gizatullin1, Petr I Mironov1 and Andеrschan U Lekmanov2*
1Bashkir State Medical University, Ufa, Republic of Bashkortostan, Russia
2Research Institute of Children’s Surgery by N. I. Pirogov Russian Research Institute Medical University, Moscow, Russia
*Corresponding Author: Andеrschan U Lekmanov, Research Institute of Children’s Surgery by N. I. Pirogov Russian Research Institute Medical University, Moscow, Russia.
Received: June 22, 2020; Published: September 09, 2020




Abstract

Purpose: Pilot development of the system estimating the risk for sepsis in newborns and determining its discrimination power.

Methods: A retrospective observational single-center study. 124 newborns with sepsis are included; 34 of them died. Kullback’s measure was used to estimate the information value of the examined clinical and laboratory variables. Disease outcome (whether survived or dead) was the response function. The discrimination power was determined using ROC-analysis.

Results: The information value of the examined clinical and laboratory variables in the newborns was analyzed as related to the risk for sepsis. Early neonatal sepsis predictors include platelet count, total protein content, body mass and neutrophil count. Discrimination power of the mentioned predictors was calculated.

Conclusion: Determination of the risk for sepsis in a newborn based on the estimation of platelet count, neutrophil count, total protein and body mass is of moderate value.

Keywords: Newborns; Sepsis; Predictors; Information Value

References

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Citation: Andеrschan U Lekmanov., et al. “Pilot Validation of Early Predictors for Neonatal Sepsis”. EC Anaesthesia 6.11 (2020): 01-07..

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