Research Article
Volume 6 Issue 9 - 2020
Preoperative Pregabalin Prolongs Spinal Anesthesia in Total Knee Arthroplasty - A Retrospective Analysis
Deniz Oguz1, Serpil Savli1, Mensure Kaya1, Sakura Kinjo2 and Suheyla Unver1
1Department of Anesthesia, Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Turkey
22Department of Anesthesia and Perioperative Care, University of California, San Francisco, Turkey
*Corresponding Author: Deniz Oguz, Department of Anesthesia, Dr. Abdurrahman Yurtaslan Ankara Oncology Education and Research Hospital, Turkey.
Received: August 26, 2020; Published: August 31, 2020




Abstract

Background: Pregabalin is a gamma aminobutyric acid analogous, which is commonly used for epilepsy, neuropathic pain and anxiety disorder. Moreover, it is becoming more commonly used for acute postoperative pain. The recent studies showed that preoperative use of pregabalin increases the duration of spinal anesthesia. Thus, we conducted a retrospective analysis to investigate whether preoperative pregabalin affect duration of spinal anesthesia in total knee arthroplasty.

Methods: 76 patients who underwent unilateral or bilateral total knee arthroplasty were included in the study. The patients were divided in two groups based on their preoperative use of pregabalin; Pregabalin Group (patients who took pregabalin (at least 150 mg/day) at home for osteoarthritis vs. Control Group (patients were not on any gabapentinoids (pregabalin or gabapentin)). Two cohorts were matched by age and gender. All patients received spinal anesthesia with 10 mg of isobaric 0.5% bupivacaine.

Results: There was no statistical difference in the time of sensory block reached to sixth thoracic dermatome in two groups. The duration of two segment regression from peak sensory block level in pregabalin group was significantly longer than control group (70 ± 22.4 min) vs. 40 ± 12.4 min, P = 0.0001). The entire duration of motor block was significantly longer in pregabalin group (200 ± 36.7min vs. 180 ± 26.5 min, P = 0.0001).

Conclusion: The duration of spinal anesthesia was longer in patients who took pregabalin as a home medication than patients who were not on this medication.

Keywords: Pregabalin; Spinal Block; Total Knee Arthroplasty

References

  1. Sills GJ. “The mechanisms of action of gabapentin and pregabalin”. Current Opinion in Pharmacology 6 (2006): 108-113.
  2. Bandelow B., et al. “Pregabalin for the treatment of generalized anxiety disorder: A novel pharmacologic intervention”. Expert Review of Neurotherapeutics 7 (2007): 769-781.
  3. Zhang J., et al. “Efficacy of pregabalin in acute postoperative pain: A meta-analysis”. British Journal of Anaesthesia 106 (2011): 454-462.
  4. Bafna U., et al. “A comparison of effect of preemptive use of oral gabapentin and pregabalin for acute post-operative pain after surgery under spinal anesthesia”. Journal of Anaesthesiology Clinical Pharmacology 30 (2014): 373-377.
  5. Park M and Jeon Y. “Preoperative pregabalin prolongs duration of spinal anesthesia and reduces early postoperative pain: A double-blind, randomized clinical consort study”. Medicine 95 (2016): e4828.
  6. Kohli M., et al. “Optimization of subarachanoid block by oral pregabalin for hysterectomy”. Journal of Anaesthesiology Clinical Pharmacology 27 (2011): 101-105.
  7. Dooley DJ., et al. “Stimulus-dependent modulation of [(3)h]norepinephrine release from rat neocortical slices by gabapentin and pregabalin”. Journal of Pharmacology and Experimental Therapeutics 295 (2000): 1086-1093.
  8. Park S., et al. “Pregabalin and gabapentin inhibit substance p-induced nf-kappab activation in neuroblastoma and glioma cells”. Journal of Cellular Biochemistry 105 (2008): 414-423.
  9. Fehrenbacher JC., et al. “Pregabalin and gabapentin reduce release of substance p and cgrp from rat spinal tissues only after inflammation or activation of protein kinase c”. Pain 105 (2003): 133-141.
  10. Sagar DR., et al. “Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain”. Arthritis and Rheumatology 62 (2010): 3666-3676.
  11. Gwilym SE., et al. “Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients”. Arthritis and Rheumatology 61 (2009): 1226-1234.
Citation: Deniz Oguz., et al. “Preoperative Pregabalin Prolongs Spinal Anesthesia in Total Knee Arthroplasty - A Retrospective Analysis”. EC Anaesthesia 6.9 (2020): 22-25.

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