Guest Editorial
Volume 6 Issue 6 - 2020
A Suggestion on Ethanol Therapy in COVID-19?
Ali Amoushahi1* and Annemarie Padmos2
1Anesthesiology and Intensive Care Department, Isabne Maryam Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
2MSc student, Master of Advanced Nursing Practice at Rotterdam University of Applied Sciences, Rotterdam University of Applied Sciences, Netherlands
*Corresponding Author: Ali Amoushahi, Anesthesiology and Intensive Care Department, Isabne Maryam Hospital, Isfahan University of Medical Sciences, Isfahan, Iran.
Received: April 28, 2020; Published: May 25, 2020

The world emergence pandemy of respiratory disease caused by new coronavirus named COVID-19 is a viral disease that may cause cytokine storm condition [1,2]. To overcome this fatal emerged situation many off-label drugs have been tried and there is not found any specific medication, yet. One off-label drug which could be use in a clinical trial is ethanol. The major basis behind the proposal of ethanol therapy in COVID-19 is related to it’s immunomodulatory effects on cytokine storm in this disease [3]. It reduces the inflammatory response and decreases LTR 2, 4, 8, 9 and IL 6 to modify the innate immune system [4,5]. The second part of efficacy of this medication is inhibitory property of ethanol on RNA polymerase respond to virus replication [6,7]. And the third reason, ethanol could involve directly with the bilayer lipid capsule of the coronavirus [8-10]. Other therapeutic effects of ethanol: bronchodilation, decreased work of breathing, anti-cough effects, sedation, and mucolytic properties. Bimodal ethanol therapy (inhalation and intravenous infusion) helps to kill the virus in two directions: a) blood-to-alveolar direction; b) upper-to-lower airway direction. A lot of researches on ethanol therapy were previously conducted in the field of methanol intoxication [11], fat embolism [12], preterm labour [13], pre-eclampsia [14], AF ablation [15], pulmonary edema [16] and many more [17,18].


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  17. Yang B., et al. “Intra-arterial ethanol embolization augments response to TACE for treatment of HCC with portal venous tumor thrombus”. BMC Cancer1 (2018): 101.
  18. Zhang P., et al. “Inhalation of alcohol vapor driven by oxygen is a useful therapeutic method for postoperative alcohol withdrawal syndrome in a patient with esophageal cancer: a case report”. Alcohol and Alcoholism4 (2011): 424-426.
  19. Cao Y. “Suggestion Using Alcohol Vaporization or Nebulization Inhalation Therapy for Pneumonitis Caused by Coronavirus”. SSRN (2020): 3545744.
  20. CFR - Code of Federal Regulations Title 21.
Citation: Ali Amoushahi and Annemarie Padmos. “A Suggestion on Ethanol Therapy in COVID-19?”. EC Anaesthesia 6.6 (2020): 01-02.

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