Abstract

Introduction: Digestive complications of non-steroidal anti-inflammatory drugs (NSAID) are sources of morbidity and mortality. Our study objective was to determine epidemiological-clinical, endoscopic and evolutionary characteristics of gastrointestinal ulcer bleeding following NSAID in take.

Methods: It is a prospective and cross-sectional study on ulcer gastrointestinal bleeding after NSAID taking observed at Surgical Intensive Care of the Joseph Ravoahangy Andrianavalona University Hospital Antananarivo, Madagascar, during a period of two years, from January 2014 to December 2015.

Results: 76 patients were retained. The average age was 48.78 +/- 15 years with a male predominance (sex ratio: 2.8). Epigastralgia (47.36%) and alcoholism (30%) were the most common history. Dental pain (30.26%) and flu (14.47%) were the main reasons for taking NSAID. Niflumic Acid (30.26%), Acetylsalicylic Acid (26.31%) and Ibuprofen (25%) were the NSAID used. 68% of the cases is self-medication. The hemorrhage is externalized in the form of hematemesis and melena in most cases (36.84%). The main ulcers localization was gastric (86.84%). Endoscopic lesions were dominated by FORREST II (65.78%). Patients evolution was favorable in the majority of cases (98.68%).

Conclusion: Ulcer digestive hemorrhages associated with NSAID are frequent in our department. In most cases, NSAID taking is a medical prescription. Mass awareness of self-medication harmful effects is essential to reduce this incidence.

Keywords: NSAID; Endoscopy; Ulcer Digestive Hemorrhage; Prognosis

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