Research Article
Volume 6 Issue 5 - 2020
Non-Steroidal Anti-Inflammatory Drugs (NSAID) Associated with Gastroduodenal Ulcer Bleeding Observed at the Surgical Intensive Care of the Joseph Ravoahangy Andrianavalona University Hospital, Antananarivo, Madagascar
Ramarolahy Rija1, Razafindraibe Faneva Angelo Parfait2*, Rivoarimanana Hanitra Mbolatiana1, Rakotoarison Ratsaraharimanana Catherine Nicole2 and Rajaonera Andriambelo Tovohery1
1Surgical Intensive Care of the Joseph Ravoahangy Andrianavalona University Hospital, Antananarivo, Madagascar
2Surgical Emergency Unit of the Joseph Ravoahangy Andrianavalona University Hospital, Antananarivo, Madagascar
*Corresponding Author: Razafindraibe Faneva Angelo Parfait, Surgical Emergency Unit of the Joseph Ravoahangy Andrianavalona University Hospital, Antananarivo, Madagascar.
Received: March 11, 2020; Published: April 29, 2020




Abstract

Introduction: Digestive complications of non-steroidal anti-inflammatory drugs (NSAID) are sources of morbidity and mortality. Our study objective was to determine epidemiological-clinical, endoscopic and evolutionary characteristics of gastrointestinal ulcer bleeding following NSAID in take.

Methods: It is a prospective and cross-sectional study on ulcer gastrointestinal bleeding after NSAID taking observed at Surgical Intensive Care of the Joseph Ravoahangy Andrianavalona University Hospital Antananarivo, Madagascar, during a period of two years, from January 2014 to December 2015.

Results: 76 patients were retained. The average age was 48.78 +/- 15 years with a male predominance (sex ratio: 2.8). Epigastralgia (47.36%) and alcoholism (30%) were the most common history. Dental pain (30.26%) and flu (14.47%) were the main reasons for taking NSAID. Niflumic Acid (30.26%), Acetylsalicylic Acid (26.31%) and Ibuprofen (25%) were the NSAID used. 68% of the cases is self-medication. The hemorrhage is externalized in the form of hematemesis and melena in most cases (36.84%). The main ulcers localization was gastric (86.84%). Endoscopic lesions were dominated by FORREST II (65.78%). Patients evolution was favorable in the majority of cases (98.68%).

Conclusion: Ulcer digestive hemorrhages associated with NSAID are frequent in our department. In most cases, NSAID taking is a medical prescription. Mass awareness of self-medication harmful effects is essential to reduce this incidence.

Keywords: NSAID; Endoscopy; Ulcer Digestive Hemorrhage; Prognosis

References

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Citation: Razafindraibe Faneva Angelo Parfait., et al. “Non-Steroidal Anti-Inflammatory Drugs (NSAID) Associated with Gastroduodenal Ulcer Bleeding Observed at the Surgical Intensive Care of the Joseph Ravoahangy Andrianavalona University Hospital, Antananarivo, Madagascar”. EC Anaesthesia 6.5 (2020): 03-07.

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