Case Report
Volume 6 Issue 5 - 2020
Septic Shock on Post-Chemotherapy Febrile Neutropenia with Pneumopathy
Rabesalama Fanojomaharavo T1*, Randriamalala Ruffin1, Randrianjaka Hery Francis1, Rajaonera Tovohery Andriambelo2 and Riel Andry Mampionona3
1University Hospital Center of Tulear, Madagascar
2Faculty of Medecine of Antananarivo, Madagascar
3Faculty of Medecine of Tulear, Madagascar
*Corresponding Author: Rabesalama Fanojomaharavo T, University Hospital Center of Tulear, Madagascar.
Received: February 26, 2020; Published: April 28, 2020




Abstract

Introduction: Febrile neutropenia is one of the most serious side effects of chemotherapy.

Case Report: We report a case of septic shock on post-chemotherapy febrile neutropenia on streptoccoccal pneumoniae in a 65-year-old woman with an oro-pharyngeal epidermoid carcinoma and broncho-pulmonary adenocarcinoma treated with chemotherapy. On admission, she is in acute respiratory failure in a febrile context with severe neutropenia at 0.5 x 108/l (50/mm3) progressing quickly to sepsis. The patient received oxygen by high concentration mask then noninvasive ventilation (NIV), vascular filling, broad spectrum antibiotics and immunomodulator. Despite all, the evolution is quickly towards a septic shock with renal failure and metabolic acidosis. In the face of a septic shock, the patient is intubated, ventilated in volume controlled mode in invasive mechanical ventilation and has required inotropic support of 1 m/hr of noradrenaline. Despite early care, she is died in a multivisceral failure state.

Conclusion: Febrile neutropenia is an oncological emergency with a mortality of > 10%. Most patients arrive with sepsis or septic shock state. Despite current therapeutic advances, the prognosis remains pejorative.

Keywords: Neutropenia; Chemotherapy; Sepsis

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Citation: Rabesalama Fanojomaharavo T., et al. “Septic Shock on Post-Chemotherapy Febrile Neutropenia with Pneumopathy”. EC Anaesthesia 6.5 (2020): 42-47.

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