Case Report
Volume 6 Issue 4 - 2020
Aspects of Interest in the Systemic Inflammatory Response Syndrome
Carlos de la Paz Estrada*
Second Degree Specialist in Anesthesiology and Resuscitation, Pediatric Teaching Hospital "Eduardo Agramonte Piña", Camagüey, Cuba
*Corresponding Author: Carlos de la Paz Estrada, Second Degree Specialist in Anesthesiology and Resuscitation, Pediatric Teaching Hospital "Eduardo Agramonte Piña", Camagüey, Cuba.
Received: October 25, 2019; Published: March 09, 2020


Inflammation can be described as a host reaction against tissue damage or the presence of pathogens. The release of mediators such as histamine, bradykinin and others cause vasodilation and increases tissue permeability, causing inflammation. This inflammation stimulates the nociceptors and produces pain. An important local inflammation can cause an acute phase systemic response. This response is manifested with the release of protein C, complement and others, and is followed by the activation of the cynin system (IL-1, IL-8, TNF) that induces chemotaxis of neutrophils at the site of injury. Some cytokines can induce fever and lymphocytic proliferation, which is typical in the water phase reaction of inflammation. This defensive response sets in motion the phagocytosis mechanisms of invasive pathogens. Inflammation, therefore, is an essential response for the structural repair of tissues damaged by multiple causes. It can also be a harmful reaction for the organism, since an excessive or disorderly response, as occurs in various diseases, can aggravate tissue structural damage; It is currently believed that modulation of this response prevents final tissue damage. As anesthesiologists, we are concerned about the disorderly effects of inflammation in lung damage, in microvascular permeability, in myocardial infarction and reperfusion damage and in acute and chronic pain.

Keywords: Inflammatory Response Syndrome; Neutrophils; Cytokines


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Citation: Carlos de la Paz Estrada. “Aspects of Interest in the Systemic Inflammatory Response Syndrome”. EC Anaesthesia 6.4 (2020): 01-07.

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