Case Report
Volume 6 Issue 4 - 2020
Aspects of Interest in the Systemic Inflammatory Response Syndrome
Carlos de la Paz Estrada*
Second Degree Specialist in Anesthesiology and Resuscitation, Pediatric Teaching Hospital "Eduardo Agramonte Piña", Camagüey, Cuba
*Corresponding Author: Carlos de la Paz Estrada, Second Degree Specialist in Anesthesiology and Resuscitation, Pediatric Teaching Hospital "Eduardo Agramonte Piña", Camagüey, Cuba.
Received: October 25, 2019; Published: March 09, 2020




Abstract

Inflammation can be described as a host reaction against tissue damage or the presence of pathogens. The release of mediators such as histamine, bradykinin and others cause vasodilation and increases tissue permeability, causing inflammation. This inflammation stimulates the nociceptors and produces pain. An important local inflammation can cause an acute phase systemic response. This response is manifested with the release of protein C, complement and others, and is followed by the activation of the cynin system (IL-1, IL-8, TNF) that induces chemotaxis of neutrophils at the site of injury. Some cytokines can induce fever and lymphocytic proliferation, which is typical in the water phase reaction of inflammation. This defensive response sets in motion the phagocytosis mechanisms of invasive pathogens. Inflammation, therefore, is an essential response for the structural repair of tissues damaged by multiple causes. It can also be a harmful reaction for the organism, since an excessive or disorderly response, as occurs in various diseases, can aggravate tissue structural damage; It is currently believed that modulation of this response prevents final tissue damage. As anesthesiologists, we are concerned about the disorderly effects of inflammation in lung damage, in microvascular permeability, in myocardial infarction and reperfusion damage and in acute and chronic pain.

Keywords: Inflammatory Response Syndrome; Neutrophils; Cytokines

References

  1. Brun-Buisson C. “The epidemiology of the systemic inflammatory response”. Intensive Care Medicine 26.1 (2000): S64-S74.
  2. Shapiro NI., et al. “The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection”. Annals of Emergency Medicine 48.5 (2006): 583-590.
  3. Bernard GR., et al. “Efficacy and safety of recombinant human activated protein C for severe sepsis”. New England Journal of Medicine 344.10 (2001): 699-709.
  4. Rivers E., et al. “Early goal-directed therapy in the treatment of severe sepsis and septic shock”. New England Journal of Medicine 345.19 (2001): 1368-1377.
  5. Shapiro NI., et al. “Mortality in Emergency Department Sepsis (MEDS) score: a prospectively derived and validated clinical prediction rule”. Critical Care Medicine 31.3 (2003): 670-675.
  6. Shapiro NI., et al. “Serum lactate as a predictor of mortality in emergency department patients with infection”. Critical Care Medicine 45.5 (2005): 524-528.
  7. Jaimes F., et al. “Comparison between logistic regression and neural networks to predict death in patients with suspected sepsis in the emergency department”. Critical Care 9.2 (2005): R150-R156.
  8. Nguyen HB., et al. “Early lactate clearance is associated with improved outcome in severe sepsis and septic shock”. Critical Care Medicine 32.8 (2004): 1637-1642.
  9. Carrillo ER. “Modulación genética de la respuesta inflamatoria sistémica en sepsis”. Revista de la Asociación Mexicana de Medicina Crítica y Terapia Intensiva 15.3 (2001): 92-95.
  10. Talan DA. “Dear SIRS: It’s time to return to sepsis as we have known it”. Annals of Emergency Medicine 48.5 (2006): 591-592.
  11. Lemieux C., et al. “Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses”. Blood 105.4 (2005): 1523-1530.
  12. Kim I., et al. “Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression”. Circulation Research 89.6 (2001): 477-479.
  13. Orfanos SE. “Angiopoietin-2 is increased in severe sepsis: Correlation with inflammatory mediators”. Critical Care Medicine 35.1 (2007): 199-206.
  14. Berger MM. “Antioxidant supplementation in sepsis and systemic inflammatory response syndrome”. Critical Care Medicine 35.9 (2007): S584-S590.
  15. Crimi E., et al. “The role of oxidative stress in adult critical care”. Free Radical Biology and Medicine 40.3 (2006): 398-406.
  16. Padeh S. “Auto-inflammatory fever syndromes”. Rheumatic Disease Clinics of North America 33.3 (2007): 585-623.
  17. Werdan K. “Immunoglobulin G treatment of postcardiac surgery patients with score-identified severe systemic inflammatory response syndrome. The ESSICS study”. Critical Care Medicine 36.3 (2008): 716-723.
  18. Pei-Ra L. “Acute effects of hyperglycemia and hyperinsulinemia on hepatic oxidative stress and the systemic inflammatory response in rats”. Critical Care Medicine 35.2 (2007): 555-560.
  19. Dong Z., et al. “Procalcitonin for the differential diagnosis of infectious and non-infectious systemic inflammatory response syndrome after cardiac operation”. Chinese 26.7 (2014): 478-479.
  20. Bauer ME., et al. “Maternal Physiologic Parameters in Relationship to Systemic Inflammatory Response Syndrome Criteria: A Systematic Review and Meta-analysis”. Obstetrics and Gynecology 124.3 (2014): 535-541.
  21. Chen L., et al. “Analysis for risk factors of systemic inflammatory response syndrome after one-phase treatment for apyrexic calculous pyonephrosis by percutaneous nephrolithotomy”. Beijing Da Xue Xue Bao 46.4 (2014): 566-569. 
  22. Talebi-Taher M., et al. “Serum Inflammatory Markers in the Elderly: Are They Useful in Differentiating Sepsis from SIRS?” Acta Medica Iranica 52.6 (2014): 438-442.
  23. Lindvig KP., et al. “How do bacteraemic patients present to the emergency department and what is the diagnostic validity of the clinical parameters temperature, C-reactive protein and systemic inflammatory response syndrome?” Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine 22.1 (2014): 39.
  24. Semler MW and Wheeler AP. “Systemic inflammatory response syndrome after cardiac surgery: time for a change”. Chest 145.6 (2014): 1181-1182.
  25. Serrano-Berrones MA and Centeno-Durán G. “Systemic inflammatory response syndrome in the obstetric patient. Case report”. Ginecologia y Obstetricia de Mexico 82.4 (2014): 257-260. 
Citation: Carlos de la Paz Estrada. “Aspects of Interest in the Systemic Inflammatory Response Syndrome”. EC Anaesthesia 6.4 (2020): 01-07.

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